Link Assembly

Link assembly is the integration of rigid or flexible links with joints to create a functional mechanical system that transmits motion and force. In an engineered linkage, connected members rotate, slide, or pivot about defined joints, while their geometry constrains relative movement and determines mechanical advantage, range of motion, and load distribution. Engineers use link assemblies in mechanisms such as robotic arms, actuators, suspension systems, and motion-control devices. Designing and analyzing these assemblies supports accurate kinematic modeling, reliable force transmission, reduced wear, and the development of machines that convert input motion into controlled output.

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Research

JoVE Journal - Biology
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Assembly, Loading, and Alignment of an Analytical Ultracentrifuge Sample Cell

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Cited by 21 •

2009

The analytical ultracentrifuge (AUC) sample cell holds sample and reference buffer and during experiments and is exposed to high vacuum and rotor speeds up to 60,000 rpm. This video will demonstrate the rigorous attention to detail necessary for assembly, loading and alignment of this very important component of an AUC experiment.

Education

JoVE Core - Molecular Biology

Covalently Linked Protein Regulators

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2020

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified. These groups modify specific amino acids in a protein.

X-linked Traits

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2021

In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”. One well-studied example of an X-linked trait is color blindness.

X-linked Traits

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2025

In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”. One well-studied example of an X-linked trait is color blindness.

Protein Complex Assembly

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2020

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types. Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes. Many viruses self-assemble into a fully functional unit using the infected host cell to...

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