Particle Counter

A particle counter is an instrument that detects and measures individual particles suspended in air, liquid, or another medium, providing data on particle concentration and size distribution. In optical systems, a sample passes through a focused light beam, and each particle scatters or blocks light; the resulting pulse is analyzed to estimate particle size and register a count, while other designs may use electrical sensing. Engineers use particle counters to monitor cleanroom contamination, evaluate air and fluid filtration, assess manufacturing processes, and verify environmental or industrial controls. These measurements support quality assurance, equipment performance, contamination prevention, and compliance with particle-control requirements.

Particle Counter - Related Videos

Research

JoVE Journal - Biology
Free Sample

Determining Cell Number During Cell Culture using the Scepter Cell Counter

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Cited by 56 •

2010

The Scepter Cell Counter is a handheld automated device that can be used to count cells, monitor cell diameter and volume, and be used to check the health and quality of cellular populations from one culture to the next.

Research

JoVE Journal - Biology
Free Sample

Determination of Mammalian Cell Counts, Cell Size and Cell Health Using the Moxi Z Mini Automated Cell Counter

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Cited by 18 •

2012

The Moxi Z miniature automated cell counter is a novel instrument that combines the Coulter Principle with patented thin-film sensor technology and a proprietary software algorithm to perform sizing and counting of a broad size range of particles as well as to determine the overall health of monodisperse mammalian cell cultures. This protocol describes the use of this instrument for counting and assessing the health of cell cultures.

Education

JoVE Core - Chemistry

Subatomic Particles

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2020

Dalton was only partially correct about the particles that make up matter. All matter is composed of atoms, and atoms are composed of three smaller subatomic particles: protons, neutrons, and electrons. These three particles account for the mass and the charge of an atom. The Discovery of the Electron The first clue about the subatomic structure came at the end of the 19th century when J.J. Thomson discovered the electron using a cathode ray tube. This apparatus consisted of a sealed glass...

Reverse Transcriptase Activity as a Marker for Virus-Like Particle Production

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2026

Source: Scarborough, R. J., et al. Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy. J. Vis. Exp. (2016).This video demonstrates a reverse transcriptase (RT) assay to assess the effect of a test RNA on virus-like particle (VLP) production. Cells are co-transfected with plasmids, and RT activity is measured as a quantitative indicator of VLP output. A decrease in RT activity reflects suppression of viral gene expression by the test RNA.

Concentration and Purification of Viral Particles

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2026

Source: Fricano-Kugler, C. J., et al. Designing, Packaging, and Delivery of High Titer CRISPR Retro and Lentiviruses via Stereotaxic Injection. J. Vis. Exp. (2016).This video demonstrates the step-by-step process for concentrating and purifying lentiviral particles from a mixed suspension containing host cell debris. The procedure utilizes centrifugation, filtration, and PEG-salt precipitation to isolate viral particles while removing soluble impurities. The final product is resuspended in a...

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