Probe Fabrication
Probe Fabrication - Related Videos
13:58
Probing C84-embedded Si Substrate Using Scanning Probe Microscopy and Molecular Dynamics
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Cited by 1 •
2016
This paper reports the nanomaterial fabrication of a fullerene Si substrate inspected and verified by nanomeasurements and molecular dynamic simulation.
15:43
Design and Fabrication of Ultralight Weight, Adjustable Multi-electrode Probes for Electrophysiological Recordings in Mice
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Cited by 29 •
2014
Understanding the neural substrates of behavior requires brain circuit ensemble recording. Because of its genetic tractability, the mouse offers a model for circuit dissection and disease mimicry. Here, a method of designing and fabricating miniaturized probes is described that is suitable for targeting deep brain structure in the mouse.
08:07
The Microfluidic Probe: Operation and Use for Localized Surface Processing
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Cited by 5 •
2009
In this video we present the microfluidic probe1 (MFP). We explain in detail how to assemble the MFP, mount it atop an inverted microscope, and align it relative to the substrate surface, and finally show how to use it to process a substrate surface immersed in a buffer solution.
07:36
Fabricating Nanogaps by Nanoskiving
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Cited by 3 •
2013
The fabrication of electrically addressable, high-aspect-ratio (> 1000:1) metal nanowires separated by gaps of single nanometers using either sacrificial layers of aluminum and silver or self-assembled monolayers as templates is described. These nanogap structures are fabricated without a clean room or any photo- or electron-beam lithographic processes by a form of edge lithography known as nanoskiving.
09:39
Procedure for Fabricating Biofunctional Nanofibers
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Cited by 1 •
2012
An efficient approach for preparing nanofibers decorated with functional groups capable of specifically interacting with proteins is described. The approach first requires the preparation of a polymer functionalized with the appropriate functional group. The functional polymer is fabricated into nanofibers by electrospinning. The effectiveness of the binding of the nanofibers with a protein is studied by confocal microscopy.
FAQs
Dimensions determine how closely a probe can interact with a target and therefore affect spatial resolution. Interfaces define how the probe connects with the system being measured, manipulated, or monitored. Engineering these features together helps match the device to physical, chemical, or biological conditions, while supporting the required sensitivity, durability, and compatibility with the operating environment.
Material selection influences whether a probe remains functional under its intended operating conditions. It must support the required structural behavior, interaction with the target system, and integration of sensing or actuation elements. Choosing suitable materials also contributes to durability and environmental compatibility, which are essential when probes are used in biomedical instrumentation, environmental monitoring, or microscopy.
These processes provide different ways to convert a design into physical probe structures. Machining forms features through direct material removal, while lithography defines patterned dimensions. Deposition adds material in controlled locations, and etching removes selected regions to shape structures or interfaces. Selecting among them depends on the desired geometry, dimensions, integrated elements, and level of miniaturization.
Development begins by defining the probe’s function, dimensions, materials, and interfaces. Engineers then form the planned structures using an appropriate process, integrate sensing or actuation elements, and operate under controlled fabrication conditions. Quality control follows to assess whether the finished device matches the design. This workflow supports reproducible measurement tools rather than one-off experimental structures.
Engineers tailor these properties by adjusting the probe’s dimensions, materials, interfaces, and integrated sensing or actuation elements. Smaller or more precisely defined features can support spatial resolution, while suitable integrated elements help address sensitivity requirements. Material and structural choices contribute to durability. The design must balance these characteristics with compatibility for the intended physical, chemical, or biological environment.
Fabricated probes support microscopy, biomedical instrumentation, environmental monitoring, and microelectromechanical systems. In these settings, they provide purpose-built tools for interacting with or measuring systems at the required scale and under relevant operating conditions. Their engineering value lies in translating a functional concept into a reproducible device that can support increasingly miniaturized technologies and controlled experimental measurements.