Surfactant Pluronic F68
Surfactant Pluronic F68 - Related Videos
09:34
Extraction and Characterization of Surfactants from Atmospheric Aerosols
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Cited by 26 •
2017
Methods are presented for the targeted extraction of surfactants present in atmospheric aerosols and the determination of their absolute concentrations and surface tension curves in water, including their Critical Micelle Concentration (CMC).
07:20
Lavage-induced Surfactant Depletion in Pigs As a Model of the Acute Respiratory Distress Syndrome (ARDS)
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Cited by 21 •
2016
Repeated pulmonary lavages in anesthetized pigs induce lung injury resembling major aspects of human acute respiratory distress syndrome (ARDS). For this purpose the lungs are repeatedly lavaged with 0.9% saline at 37 °C. The goal of the protocol is a reproducible mitigation of gas exchange and hemodynamics for research in ARDS.
10:28
Experimental Measurement of Settling Velocity of Spherical Particles in Unconfined and Confined Surfactant-based Shear Thinning Viscoelastic Fluids
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Cited by 15 •
2014
This paper demonstrates the experimental procedure to measure terminal settling velocities of spherical particles in surfactant-based shear thinning viscoelastic fluids. Fluids over a wide range of rheological properties are prepared and settling velocities are measured for a range of particle sizes in unbounded fluids and fluids between parallel walls.
06:22
Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
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Cited by 5 •
2021
A combination of surfactant washout using 0.9% saline (35 mL/kg body weight, 37 °C) and high tidal volume ventilation with low PEEP to cause moderate ventilator induced lung injury (VILI) results in experimental acute respiratory distress syndrome (ARDS). This method provides a model of lung injury with low/limited recruitability to study the effect of various ventilation strategies for extended periods.
06:31
Studying Surfactant Effects on Hydrate Crystallization at Oil-Water Interfaces Using a Low-Cost Integrated Modular Peltier Device
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Cited by 2 •
2020
We present a protocol to study the formation of hydrates in the presence of nonionic surfactants on the interface of a water droplet submerged in cyclopentane. The protocol consists of building a low-cost, programmable, temperature regulator. The temperature control system is combined with visualization techniques and internal pressure measurements.
FAQs
The polymer’s block structure determines how it behaves at interfaces: the hydrophobic polypropylene oxide segment associates with less water-compatible regions, while hydrophilic polyethylene oxide chains remain compatible with the surrounding liquid. This arrangement allows Pluronic F68 to occupy air–liquid or solid–liquid boundaries, where it lowers interfacial stress and supports more stable handling of sensitive materials.
Interfacial stress becomes especially important when engineered systems experience agitation or flow. Under these conditions, Pluronic F68 helps shield cell membranes and particles from mechanical stress, which can otherwise contribute to damage or aggregation. The practical result is improved cell viability and suspension stability, making the surfactant useful in processes that require consistent material behavior during handling.
Its protective value is most relevant in systems exposed to agitation, flow, or air–liquid and solid–liquid interfaces. These conditions create situations in which cells or particles may experience shear-induced damage or aggregation. Applying the surfactant in such environments connects its interfacial behavior with engineering goals such as maintaining stable suspensions and improving process consistency.
In mammalian cell culture and stirred bioreactors, Pluronic F68 is used to help protect cells during operation. Its role is particularly relevant when agitation or flow could affect membrane integrity or cell performance. By supporting cell viability under these processing conditions, it can contribute to more reliable suspension-based culture and improved consistency in bioreactor operation.
Useful outcomes include cell viability, suspension stability, and overall process consistency. In cell-based systems, viability indicates whether the operating environment is damaging the cells. For particle-containing systems, suspension stability reflects whether aggregation is being controlled. Evaluating these outcomes under relevant agitation or flow conditions helps connect surfactant use with practical engineering performance.
The surfactant is also used in pharmaceutical formulations and drug-delivery research, where controlling interfaces and protecting sensitive materials are important. In these settings, its interfacial action can support suspension stability and reduce aggregation. These applications extend the engineering relevance of Pluronic F68 from bioreactor operation to formulation design and delivery-oriented research.