Hemichain Centricity
Hemichain Centricity - Related Videos
08:48
Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain
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Cited by 3 •
2016
Herein we describe a novel method to generate antigen-specific T cell receptors (TCRs) by pairing the TCRα or TCRβ of an existing TCR, possessing the antigen-specificity of interest, with complementary hemichain of the peripheral T cell receptor repertoire. The de novo generated TCRs retain antigen-specificity with varying affinity.
01:17
Design of Columns under a Centric Load
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2024
The design of columns under centric load is a fundamental aspect of structural engineering and is critical for ensuring the stability and integrity of structures. Euler's and Secant's formulas are central to understanding and calculating the critical load and deformation behaviors of columns, providing a basis for safe and effective structural design. Euler's formula is applicable under the assumption that the column is a perfect, straight, homogenous prism, and it is operating within the...
11:36
An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
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Cited by 2 •
2023
Gene expression is regulated by interactions of gene promoters with distal regulatory elements. Here, we descirbe how low input Capture Hi-C (liCHi-C) allows the identification of these interactions in rare cell types, which were previously unmeasurable.
16:44
Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging
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Cited by 15 •
2009
We suggest a Born normalized approach for Optical Projection Tomography (BnOPT) that accounts for the absorption properties of imaged samples to obtain accurate and quantitative fluorescence tomographic reconstructions. We use the proposed algorithm to reconstruct the fluorescence molecular probe distribution within small animal organs.
09:47
A Methodological Protocol and Considerations for Transcranial Ultrasonic Stimulation in Exploratory Clinical Human Studies
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2025
Transcranial ultrasonic stimulation (TUS) is a promising non-invasive technique capable of stimulating the human brain at any depth, offering new therapeutic possibilities to treat various neurological conditions. This protocol provides a standardized yet adaptable empirical framework for applying TUS in neurotypical adults and patients with neurological diseases such as stroke.
FAQs
A hemichain becomes influential when its variable-region features make key contacts with the peptide–major histocompatibility complex. Those contacts can contribute strongly to recognition and specificity, even when the partner chain differs. This relationship helps explain why receptor variants with distinct full-chain sequences may still show related antigen-recognition behavior.
Recognition can remain focused on shared contacts made by one dominant chain, while the partner chain contributes less decisive variation. As a result, changes in the partner chain do not necessarily eliminate recognition of the same peptide–major histocompatibility complex. This provides a mechanistic basis for related receptors that differ in one chain yet retain common antigen specificity.
V(D)J recombination generates variable receptor chains with different sequence features. Occasionally, one resulting chain contains features particularly well suited to contacting a peptide–major histocompatibility complex. When those contacts dominate recognition, the chain can impose a recognizable specificity pattern across receptors with different partner chains, linking recombination outcomes to shared antigen responses.
Full receptor sequences can differ because their partner chains vary, while a recurring hemichain may preserve the most important antigen-recognition feature. Examining this pattern helps distinguish diversity in receptor pairing from diversity in antigen specificity. It also supports identification of shared or public clonotypes, particularly when complete receptor information is unavailable.
Researchers can examine the available chain for variable-region features associated with antigen recognition and compare recurring sequences across receptor datasets. A repeated hemichain may provide useful evidence for related antigen-specific clonotypes even without the partner sequence. This approach extends repertoire interpretation beyond complete receptor pairs while preserving attention to specificity.
In infection research, recurring antigen-associated hemichains can help characterize T-cell repertoires responding to an infectious antigen. Shared or public clonotypes may reveal patterns that occur across samples, while partial sequence data can still provide interpretable signals. The concept therefore supports tracking repertoire features linked to infection-related immune responses without requiring every receptor chain to be fully resolved.
Vaccine studies can use this concept to examine whether immunization is associated with recurring antigen-specific receptor patterns. A dominant hemichain may make related clonotypes recognizable even when partner chains differ, helping researchers assess shared repertoire features after vaccination. These observations can contribute to evaluating the structure and consistency of vaccine-associated T-cell responses.