Iga Antibodies
Iga Antibodies - Related Videos
10:27
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Cited by 10 •
2011
Dermatitis herpetiformis (DH) is a chronic inflammatory condition characterized by an autoimmune reaction between IgA and epidermal transglutaminase (eTG). DH develops in a very small portion of gluten-sensitive and/or celiac patients. The results of this study indicate that DH can also develop in a rhesus monkey host with symptoms of idiopatic dermatitis.
13:21
Antibody Generation: Producing Monoclonal Antibodies Using Hybridomas
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2023
Source: Frances V. Sjaastad1,2, Whitney Swanson2,3, and Thomas S. Griffith1,2,3,4 1 Microbiology, Immunology, and Cancer Biology Graduate Program, University of Minnesota, Minneapolis, MN 55455 2 Center for Immunology, University of Minnesota, Minneapolis, MN 55455 3 Department of Urology, University of Minnesota, Minneapolis, MN 55455 4 Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455 Polyclonal antibodies are defined as a collection of antibodies directed against...
01:10
Antibody Structure
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2019
Overview Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding. The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains Antibodies consist of four polypeptide chains: two identical heavy...
12:55
Scalable High Throughput Selection From Phage-displayed Synthetic Antibody Libraries
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Cited by 33 •
2015
A method is described with visual accompaniment for conducting scalable, high throughput selections from phage-displayed combinatorial synthetic antibody libraries against hundreds of antigens simultaneously. Using this parallel approach, we have isolated antibody fragments that exhibit high affinity and specificity for diverse antigens that are functional in standard immunoassays.
03:18
Antibody-Dependent Enhancement of Zika Virus by Dengue Antibodies in Human Primary Macrophages
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2026
Source: Asad, S., et al. Quantification of Antibody-dependent Enhancement of the Zika Virus in Primary Human Cells. J. Vis. Exp. (2019)This video demonstrates antibody-dependent enhancement of Zika virus infection in human primary macrophages, using dengue antibody–virus complexes to model how cross-reactive antibodies facilitate Fcγ receptor–mediated viral entry and replication for studying infection mechanisms and immune interactions.
FAQs
The J chain links two IgA units into a dimer that can engage the polymeric immunoglobulin receptor on epithelial cells. This receptor-mediated pathway moves the antibody across the epithelial layer, positioning it where microbes and toxins encounter mucosal defenses. The transport mechanism therefore connects antibody production in underlying tissues with protection at the surface.
IgA can bind microbes and toxins before they attach to epithelial cells, limiting their access to the mucosal surface. This process, known as immune exclusion, helps defend the respiratory and gastrointestinal tracts while avoiding the strong inflammatory damage that can accompany more aggressive immune reactions. Its value lies in protection that preserves barrier tissues.
Plasma cells located in mucosal tissues, including the respiratory and gastrointestinal tracts, provide a local source of IgA. Their position supports antibody delivery to nearby epithelial surfaces, where the molecules can interact with invading microbes or toxins. This tissue-based production is important when studying how immune defense is organized at body entry sites.
IgA response studies can show how vaccination relates to antibody-mediated defense at mucosal surfaces. Because IgA acts where pathogens may encounter respiratory or gastrointestinal epithelium, this research connects vaccine investigation with immune exclusion and prevention of microbial attachment. The same work can also clarify how mucosal immunity contributes to protection against infection.
In infection research, investigators can examine IgA as part of the body's defense against microbes and toxins at mucosal surfaces. Studying these responses helps frame how immune exclusion limits pathogen access to epithelial cells. This focus links antibody biology with the mechanisms that influence whether infectious agents can establish contact with vulnerable tissues.
IgA research extends beyond infection because allergy and disorders involving impaired antibody production are important clinical and scientific contexts. Examining IgA in these settings can relate mucosal antibody biology to altered immune defense. The comparison is useful for understanding how changes in antibody production may affect protection at respiratory or gastrointestinal surfaces.