Adjacent Segment Degeneration

Adjacent segment degeneration is the progressive wear of spinal motion segments next to a previously fused vertebral level, a clinically important phenomenon because it can alter spinal function and contribute to new symptoms. After fusion removes motion at one segment, load and movement may be redistributed to neighboring discs and facet joints, potentially accelerating disc degeneration, joint changes, and spinal narrowing. In medicine, recognizing this process helps clinicians interpret postoperative imaging, distinguish radiographic degeneration from symptomatic adjacent segment disease, and evaluate back or neck pain, radiculopathy, or myelopathy. It also informs surgical planning, follow-up, and research into motion-preserving treatments.

Adjacent Segment Degeneration - Related Videos

Research

JoVE Journal - Neuroscience
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Transforaminal Full-Endoscopic Lumbar Foraminotomy Under Local Anesthesia for L5/S1 Adjacent Segment Foraminal Stenosis

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Cited by 1 •

2025

This protocol provides a step-by-step guide for performing transforaminal full-endoscopic foraminotomy under local anesthesia. This motion-preserving technique is presented as a minimally invasive surgical alternative to fusion extension for treating L5/S1 foraminal stenosis in patients with adjacent segment disease.

Research

JoVE Journal - Biology
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Automated Joint Space Detection Improves Bone Segmentation Accuracy

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2025

The development of an automated joint space detection workflow enabled high-throughput segmentation of distinct murine hindpaw bones with >98% accuracy in wild-type animals. Flexible application to forepaws and paws with inflammatory-erosive arthritis was achieved, but with deprecated performance that warrants further optimization in future studies using publicly available data.

Research

JoVE EoE - Neuropathology

Assessing Neuronal Degeneration in Mouse Brain Sections Using Silver Staining

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2025

Add double-distilled water to wash the sections.

Anterior Eye Segment Dissection: A Method to Isolate Cornea Bearing Anterior Segment from Porcine Eye

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2025

In this video, we demonstrate the dissection of the cornea-bearing anterior segment of the porcine eye. The isolated segment can be used for organ culturing to study the pathophysiology of eye disorders.

Research

JoVE Journal - Biology
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Volume Segmentation and Analysis of Biological Materials Using SuRVoS (Super-region Volume Segmentation) Workbench

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Cited by 10 •

2017

Segmentation of three-dimensional data from many imaging techniques is a major bottleneck in analysis of complex biological systems. Here, we describe the use of SuRVoS Workbench to semi-automatically segment volumetric data at various length-scales using example datasets from cryo-electron tomography, cryo soft X-ray tomography, and phase contrast X-ray tomography techniques.

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