Anastomotic Leak
Anastomotic Leak - Related Videos
04:05
Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy
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2025
Here, we present a protocol for endoscopic vacuum therapy (EVT) in the management of anastomotic leaks following total gastrectomy with esophagojejunostomy.
05:42
Development of a Murine Model for Femoral Artery Anastomotic Stenosis
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2025
Here we present a murine model for femoral artery anastomosis, offering researchers a valuable animal model to study and simulate vascular anastomotic stenosis. This development is crucial for advancing our understanding of the pathophysiology underlying this condition and facilitating more accurate and effective research into vascular diseases.
06:39
An Optimized Evans Blue Protocol to Assess Vascular Leak in the Mouse
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Cited by 68 •
2018
In this article, an economical, optimized, and simple protocol is described which uses the Evans blue dye method for assessing plasma extravasation in the organs of FVBN mice that can be adapted for use in other strains, species, and other organs or tissues.
06:59
Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation
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Cited by 2 •
2020
Intrathecally applied fluorescein is used to achieve intraoperative visualization of CSF leaks. This protocol describes a lumbar puncture, the application of 5% fluorescein, and intraoperative visualization using a fully digital microscope.
09:40
An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function
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Cited by 3 •
2020
We describe a novel intrathoracic esophagogastric anastomotic technique designed to create a large diameter anastomosis while simultaneously maintaining conduit blood supply to minimize the incidence of anastomotic leaks and strictures. Construction and orientation of the stomach conduit designed to optimize upper gastrointestinal tract function is also described.
FAQs
Blood supply is a central determinant of anastomotic healing. When circulation to the surgically connected tissues is inadequate, the healing process may be disrupted, reducing the likelihood that the connection will seal securely. This mechanism makes preservation of adequate blood supply an important consideration in risk assessment and postoperative care.
Tension can interfere with the tissues’ ability to heal at the surgical connection, while infection can further disrupt tissue repair. These factors may act together, weakening the healing process and increasing the likelihood of leakage. Recognizing their contribution helps clinicians evaluate risk and focus prevention efforts on optimized surgical technique and postoperative management.
Disrupted healing can allow local inflammation to develop around the affected connection and may lead to abscess formation. In more severe cases, the inflammatory response can become systemic and produce infection throughout the body. These possible outcomes explain why early recognition and appropriate intervention are important after surgery.
Evaluation combines clinical assessment with imaging. Clinical evaluation helps identify findings that raise concern for a postoperative complication, while imaging can provide additional information about the affected area and surrounding tissues. Using both approaches supports timely diagnosis, which is important because delayed recognition may allow inflammation, abscess formation, or systemic infection to progress.
Optimized surgical technique is a central preventive strategy. It should account for conditions that can disrupt healing, including inadequate blood supply and excessive tension at the connection. Prevention also depends on recognizing patient or tissue factors that impair repair. These measures aim to lower postoperative morbidity and reduce the need for further surgery.
Anastomotic leak is important because it can contribute to localized inflammation, abscess formation, systemic infection, prolonged hospitalization, and further surgery. In clinical medicine, the complication guides risk assessment, postoperative monitoring, diagnosis, prevention, and management. In research, these same outcomes provide meaningful measures for evaluating surgical technique and intervention strategies.