Atherogenic Index
Atherogenic Index - Related Videos
09:14
The Rabbit Model of Accelerated Atherosclerosis: A Methodological Perspective of the Iliac Artery Balloon Injury
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Cited by 16 •
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Animal models of atherosclerosis are essential to understand the mechanism and to investigate newer approaches to prevent plaque development or rupture, a leading cause of death in the industrialized world. This protocol uses a combination of balloon injury and cholesterol rich diet to induce atherosclerotic plaques in rabbit iliac artery.
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On-Chip Endothelial Inflammatory Phenotyping
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Cited by 3 •
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Microfluidic flow chambers etched by photolithography and fabricated from PDMS are applied to probe functional outcomes associated with EC dysfunction and inflammation. In a representative experiment, the ability of differential shear stress to modulate monocytic cell adhesion to cytokine activated EC monolayers is demonstrated.
FAQs
The calculation uses the triglyceride-to-high-density lipoprotein cholesterol ratio after converting both measurements to molar concentrations. A base-10 logarithm is then applied to that ratio. Using molar rather than mass concentrations is important because the index is defined around the relative relationship between these two lipid components, not their unadjusted numerical values.
The value generally rises when triglycerides increase relative to HDL cholesterol and falls when HDL cholesterol is higher relative to triglycerides. This direction reflects a less favorable or more favorable balance between the measured lipoprotein-related components. Interpretation should remain connected to the complete lipid profile and the patient’s broader cardiovascular risk factors.
Higher values may be associated with small, dense low-density lipoprotein particles, which provide additional information about the character of the lipid profile beyond routine cholesterol concentrations. This relationship helps connect the index with a potentially more atherogenic pattern and supports research into how dyslipidemia relates to atherosclerosis and cardiovascular risk.
The calculation requires triglyceride and high-density lipoprotein cholesterol results, expressed as molar concentrations before applying the base-10 logarithm to their ratio. In clinical practice, these values come from a lipid panel. The resulting measure is then considered with the remaining lipid results rather than treated as an isolated laboratory finding.
Clinicians may use the index alongside lipid panels, medical history, and other risk factors when assessing cardiovascular risk. It can add context when triglyceride and HDL cholesterol patterns suggest an unfavorable lipid balance. The measure supports assessment but does not replace broader clinical evaluation or interpretation of the patient’s overall risk profile.
Researchers can examine the index as a calculated marker when studying relationships among dyslipidemia, insulin resistance, and atherosclerosis. Its association with a more atherogenic lipid profile provides a way to compare lipid patterns across investigations. The measure is therefore useful for exploring metabolic abnormalities while preserving the need to interpret findings within the wider study context.