Clinical Pathologic Correlation
Clinical Pathologic Correlation - Related Videos
11:16
Correlative Light- and Electron Microscopy Using Quantum Dot Nanoparticles
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Cited by 12 •
2016
A method is described whereby quantum dot (QD) nanoparticles can be used for correlative immunocytochemical studies of epoxy embedded human pathology tissue. We employ commercial antibody fragment conjugated QDs that are visualized by widefield fluorescence light microscopy and transmission electron microscopy.
04:14
Expansion Pathology: A Method for High-resolution Optical Imaging of Clinical Tissue Samples
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2023
In this video, we describe a method called expansion pathology, a variant of expansion microscopy, wherein the clinical tissue specimens are chemically expanded using a polymer network for microscopic examination of nanoscale structures.
08:29
Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
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Cited by 7 •
2016
Organized brain cutting procedures are necessary to correlate specific neuropsychiatric phenomena with definitive neuropathologic diagnoses. Brain cuttings are performed differently based on various clinico-academic contingencies. This protocol describes a symmetric bihemispheric brain cutting procedure to investigate hemispheric differences in human brain pathologies and to maximize current and future biomolecular/neuroimaging techniques.
02:20
Correlations
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2020
Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
11:20
Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology
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Cited by 7 •
2018
Obtaining high-quality genomic DNA from tumor tissues is an essential first step for analyzing genetic alterations using next generation sequencing. In this article, we present a simple and rapid method to enrich tumor cells and obtain intact DNA from touch imprint cytology specimens.
FAQs
The central reasoning step is to test whether the pathological abnormality accounts for the patient’s findings. Clinicians compare it with the history, symptoms, physical examination, laboratory results, and imaging. Concordance strengthens the diagnosis, whereas a mismatch suggests that the observed abnormality may be incomplete or may not explain the clinical problem.
Clinical pathologic correlation improves differential diagnosis by connecting disease mechanisms to recognizable findings. When several diseases produce similar symptoms, the pathological pattern can reveal which process best fits the clinical picture, while the clinical context helps determine whether a tissue finding is meaningful. This comparison supports more focused and informed diagnostic reasoning.
Gross and microscopic tissue changes should be interpreted together rather than in isolation. Their relationship to the clinical presentation and to laboratory or imaging results helps determine whether the pathological abnormality explains the patient’s condition. This integrated reading is especially useful when a single tissue observation is difficult to interpret without the broader clinical context.
A practical workflow begins with the patient’s history, symptoms, and physical examination, followed by review of laboratory and imaging results. Clinicians then compare these findings with gross and microscopic tissue changes. The final assessment asks whether the pathological findings account for the clinical presentation, whether alternative explanations remain, and how the combined evidence supports diagnosis.
Clinicopathologic conferences organize clinical information and pathological findings around a specific patient or disease problem. Reviewing the evidence together allows clinicians and pathologists to explain discrepancies, clarify disease mechanisms, and communicate more effectively. The discussion can also show how a pathological interpretation relates to the patient’s symptoms, diagnostic workup, and overall clinical course.
By showing how pathological changes relate to the patient’s actual presentation, clinical pathologic correlation provides a stronger basis for interpreting the significance of disease findings. That interpretation can inform management decisions and help clarify prognosis. Its value is greatest when pathological evidence is considered alongside the complete clinical picture rather than treated as an isolated result.