Intravascular Biologics
Intravascular Biologics - Related Videos
07:29
Intravascular Delivery of Biologics to the Rat Kidney
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Cited by 1 •
2016
The administration of drugs for recovery of kidney function requires control of the localization and distribution of the therapeutic compound. Here, we describe in detail a simple technique for intrarenal delivery of drugs in rats. This procedure may be easily performed with no mortality and high reproducibility.
09:43
In vivo Near Infrared Fluorescence (NIRF) Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis
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Cited by 32 •
2011
We detail a new near-infrared fluorescence (NIRF) catheter for 2-dimensional intravascular molecular imaging of plaque biology in vivo. The NIRF catheter can visualize key biological processes such as inflammation by reporting on the presence of plaque-avid activatable and targeted NIR fluorochromes. The catheter utilizes clinical engineering and power requirements and is targeted for application in human coronary arteries. The following research study describes a multimodal imaging strategy...
07:28
Synthetic Biology
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2023
This video presents synthetic biology and its role in bioengineering. Synthetic biology refers to the methods used to genetically modify organisms in order to make them capable of producing large quantities of a product. This product could be a protein that the cell already makes or a new protein that has been encoded in a newly-inserted DNA sequence. Here, we discuss how an organism's genetic material is modified using transformation or transfection. Then, the process is shown in the...
01:57
What is Conservation Biology?
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2019
Conservation biology is a scientific field that focuses on the preservation of biodiversity in order to protect ecosystems while meeting the needs of the human population. Humans require properly functioning ecosystems to maintain our supply of natural resources, including food, medicines, and building materials. Ecosystems also perform critical services, such as purifying our air and water. A large body of evidence indicates that such ecosystem services depend on biodiversity. Furthermore,...
05:51
Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
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Cited by 18 •
2016
Here, we describe a simple method of intracerebroventricular and intravascular injection of viral particles or fluorescent microbeads into the neonatal mouse brain. The localization pattern of the virus and nanoparticles could be detected by microscopic evaluation or by in situ hybridization.
FAQs
Distribution determines how widely an agent travels after entering the bloodstream and whether it reaches intended tissues. Clearance removes the agent from circulation, limiting the duration or intensity of exposure. Together, these processes influence pharmacokinetics, the study of how concentrations change over time, and help explain differences between therapeutic activity and unintended effects.
Blood components and vascular surfaces can interact with a biologic before it reaches its target tissue. These interactions may affect where the agent travels, how available it remains for receptor binding, and how the body recognizes or removes it. Considering these interfaces is therefore important when evaluating distribution, therapeutic targeting, and safety.
Direct vascular delivery avoids exposure to gastrointestinal breakdown that could otherwise affect a biological agent before it enters circulation. The agent can therefore circulate systemically, making its effects dependent more directly on vascular distribution, target-tissue access, receptor binding, immune recognition, and clearance. This provides a basis for studying controlled therapeutic exposure in medicine.
Development should consider the selected vascular route, the agent's interactions with blood and vascular surfaces, its distribution to target tissues, and its clearance from circulation. Investigators also need to examine receptor binding and immune recognition because these processes can influence activity and unintended effects. Together, these factors connect delivery decisions with efficacy, pharmacokinetics, and safety.
The approach can include antibodies, proteins, nucleic-acid-based agents, and living cells. These formats provide different therapeutic strategies while sharing the need to function within the bloodstream and reach relevant tissues. Studying them in a common vascular framework helps investigators compare distribution, receptor interactions, immune recognition, clearance, and the resulting balance between efficacy and safety.
In medicine, these agents support treatment strategies that depend on systemic circulation and access to target tissues. They also provide a framework for investigating vascular delivery, pharmacokinetics, safety, and therapeutic targeting. Research outcomes can clarify why an agent produces a desired effect, how long it remains available, and which factors may contribute to unintended biological responses.