Female Rodent Model
Female Rodent Model - Related Videos
07:42
Nerve-sparing Mid-urethral Obstruction (NeMO) in Female Small Rodents
0 Views •
Cited by 7 •
2017
Traditional modeling of partial bladder outlet obstruction in rodents is fraught with animal mortality. A denervation injury from dissection around the proximal urethra and bladder neck is also of major concern. We developed and evaluated a safe and reliable mid-urethral obstruction model, avoiding the shortcomings of the traditional model.
10:29
Principles of Rodent Surgery for the New Surgeon
0 Views •
Cited by 56 •
2011
Before attempting surgery, a new surgeon should have training in basic surgical techniques and concepts. This article will present basic surgical considerations with an emphasis on rodents.
12:59
Barnes Maze Testing Strategies with Small and Large Rodent Models
0 Views •
Cited by 171 •
2014
The dry-land Barnes maze is widely used to measure spatial navigation ability in response to mildly aversive stimuli. Over consecutive days, performance (e.g. latency to locate escape cage) of control subjects improves, indicative of normal learning and memory. Differences between rats and mice necessitate apparatus and methodology changes that are detailed here.
02:54
Establishment of a Urinary Tract Infection Model in Female Mice
0 Views •
2025
This video demonstrates the establishment of uropathogenic Escherichia coli infection in a female mouse bladder through transurethral catheter instillation. The injected bacteria successfully establish a urinary tract infection within the bladder, providing a valuable platform for studying healthcare-associated diseases related to the urinary tract.
09:40
Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension
0 Views •
Cited by 35 •
2016
Pulmonary arterial hypertension (PAH) is a disease of pulmonary arterioles that leads to their obliteration and the development of right ventricular failure. Rodent models of PAH are critical in understanding the pathophysiology of PAH. Here we demonstrate hemodynamic characterization, with right heart catheterization and echocardiography, in the mouse and rat.
FAQs
Ovarian hormones and cycle stage can influence immune function, metabolism, reproduction, and drug responses, so measurements may vary with reproductive status. This biological variation is not merely experimental noise: it can reveal sex-specific physiology or treatment effects. Recording or controlling cycle-related status helps investigators determine whether an observed outcome reflects the intervention, reproductive biology, or both.
Reproductive status serves as an important experimental variable rather than a background characteristic. Researchers can monitor it or control it according to the study design, then interpret findings in light of possible hormonal effects. This approach is especially relevant when evaluating immune, metabolic, reproductive, or pharmacological outcomes, because cycle-associated changes may alter baseline measurements and responses to treatment.
Female animals help expose biological variation that studies using only males may miss. Comparing responses across sexes can show whether disease mechanisms, drug effects, or safety findings are consistent or sex-specific. That evidence strengthens judgments about how broadly a result may apply and supports clinical study designs that account for variation in human patient populations.
Researchers should treat reproductive status as a planned study variable. They may monitor it to examine cycle-related effects or control it when reducing that source of variation is necessary for the research question. In either case, the design should specify how status was handled, allowing drug, disease, or physiological outcomes to be interpreted more consistently.
These models support investigations of cancer, cardiovascular disease, neurodegenerative disease, pharmacology, and therapeutic safety in addition to reproductive disorders. Their value extends beyond identifying disease-related changes: researchers can examine how female physiology and reproductive status influence disease processes or treatment responses, helping reveal findings that might be missed without female subjects.
These models connect biological observations with questions about treatment response and safety. In pharmacology, researchers can examine whether responses vary with sex or reproductive status; in disease studies, they can assess how findings relate to female physiology. Such evidence helps determine whether laboratory results should inform broader clinical investigation or require sex-specific consideration.