Fistula Closure
Fistula Closure - Related Videos
05:53
Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium
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Cited by 5 •
2016
After puncturing the aorta through the inferior vena cava (IVC) to create an aorto-caval fistula in the mouse, solution containing a drug is infused into the IVC via the same needle, followed by incubation. This method enables more robust drug delivery to the venous endothelium compared to the external route.
06:12
Technical Aspects of the Mouse Aortocaval Fistula
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Cited by 30 •
2013
The goal is to produce an arteriovenous fistula that is simple and reproducible. This method does not use sutures or glue adhesive. Therefore the samples can be used with the least amount of foreign materials for analysis.
10:10
A Novel Murine Model of Arteriovenous Fistula Failure: The Surgical Procedure in Detail
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Cited by 24 •
2016
Here we present a murine model of arteriovenous fistula (AVF) failure in which a clinically relevant anastomotic configuration is incorporated. This model can be used to study the pathophysiology and to test possible therapeutic interventions.
07:37
Neural Tube Closure in Mouse Whole Embryo Culture
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Cited by 22 •
2011
A method allowing for direct pharmacological manipulation of mouse embryos during neurulation that bypasses maternal metabolism is described. The technique can be adapted to study different aspects of neurulation by varying the time point and pharmacological agent.
28:13
Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Cited by 11 •
2013
Catheter ablation is combined with placement of the WATCHMAN Left Atrial Appendage Closure Device to prevent ischemic stroke in a patient with non-valvular atrial fibrillation.
FAQs
The fistula’s anatomy, underlying disease, tissue quality, and risk of recurrence guide treatment selection. Location determines whether surgery or an endoscopic approach is practical, while the condition of surrounding tissue influences whether sutures, clips, or tissue sealants can be used effectively. This individualized assessment helps match the repair method to the specific clinical problem.
Ongoing infection and inflammation can interfere with healthy tissue coming together and may sustain leakage through the fistula tract. Treatment therefore includes controlling these processes and, when needed, eliminating or draining the tract before or as part of closure. Addressing these factors supports healing and helps reduce recurrent infection and continuing tissue damage.
These options provide different ways to bring tissue together or seal the abnormal passage. Surgery can address the tract directly, while endoscopic techniques approach selected fistulas through internal pathways. Sutures, clips, and tissue sealants may be chosen according to the fistula’s location, anatomy, tissue quality, and cause. The treatment plan depends on which method can achieve secure closure.
Assessment focuses on identifying the fistula’s anatomy, determining its cause, and evaluating the quality of the surrounding tissue. Clinicians also consider infection, inflammation, ongoing leakage, and the likelihood of recurrence. These findings establish whether the tract should be eliminated or drained and help determine whether surgery, an endoscopic technique, sutures, clips, or sealants are appropriate.
Closing the fistula can restore more normal anatomy and reduce ongoing leakage between the involved surfaces. In medicine, treatment may relieve pain and discharge while limiting functional complications, recurrent infection, and tissue damage. The expected outcome depends on the fistula’s cause, anatomy, tissue condition, and risk of recurrence, so closure does not remove the need for clinical assessment.
Fistula closure is considered when an abnormal connection causes persistent leakage, infection, pain, discharge, or functional problems. Its relevance extends across fistulas involving organs, skin, or blood vessels, but the appropriate intervention varies with location and cause. Clinicians use the available anatomical and tissue information to select a repair strategy that supports normal function and limits recurrence.