Gentlewave G4

GentleWave G4 is an endodontic treatment system designed to clean and disinfect the complex internal anatomy of teeth during root canal therapy. The system delivers irrigating solutions into the prepared tooth while using multisonic energy and fluid dynamics to activate the solutions and promote their movement through the main canal and connected spaces. This approach supports the removal of tissue remnants, debris, and microorganisms while reducing reliance on manual instrumentation alone. In medicine and dentistry, GentleWave G4 is used as part of nonsurgical root canal procedures, with the goal of improving canal debridement, supporting tissue preservation, and contributing to predictable treatment outcomes.

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Research

JoVE Journal - Biochemistry

A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1

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Cited by 6 •

2017

G4 Resolvase1 binds to G-quadruplex (G4) structures with the tightest reported affinity for a G4-binding protein and represents the majority of the G4-DNA unwinding activity in HeLa cells. We describe a novel protocol that harnesses the affinity and ATP-dependent unwinding activity of G4-Resolvase1 to specifically purify catalytically active recombinant G4R1.

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

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Cited by 5 •

2016

This protocol describes the preparation and characterization of a dendrimeric magnetic resonance imaging (MRI) contrast agent that carries cyclen-based macrocyclic chelates coordinating paramagnetic gadolinium ions. In a series of MRI experiments in vitro, this agent produced an amplified MRI signal when compared to the commercially available monomeric analogue.

Protocol for Assessing the Relative Effects of Environment and Genetics on Antler and Body Growth for a Long-lived Cervid

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Cited by 2 •

2017

Phenotypic differences among cervid populations may be related to population-level genetics or nutrition; discerning which is difficult in the wild. This protocol describes how we designed a controlled study where nutritional variation was eliminated. We found that phenotypic variation of male white-tailed deer was more limited by nutrition than genetics.

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