Human Tissue
Human Tissue - Related Videos
07:48
Working with Human Tissues for Translational Cancer Research
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Cited by 4 •
2015
Translational cancer research is dependent on extraction of human tissues. Much work has gone into optimizing extraction methods for ex vivo analysis. Here, we describe tissue processing methods allowing for maximal data output from limited samples.
11:12
Tissue Engineering of a Human 3D in vitro Tumor Test System
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Cited by 34 •
2013
Methods to create human 3D tumor tissues as test systems are described. These technologies are based on a decellularized Biological Vascularized Scaffold (BioVaSc), primary human cells and a tumor cell line, which can be cultured under static as well as under dynamic conditions in a flow bioreactor.
11:31
A Chromatin Assay for Human Brain Tissue
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Cited by 16 •
2008
Until recently, expression studies on human brain were limited to quantification of RNA or protein. With the chromatin immunoprecipitation techniques described in this paper, it will be possible to map histone methylation and other epigenetic regulators of gene expression in postmortem brain.
03:56
Performing Immunohistochemistry on a Non-Human Primate Brain Tissue
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2025
Source: Eid, L. & Parent, M. Preparation of Non-human Primate Brain Tissue for Pre-embedding Immunohistochemistry and Electron Microscopy. J. Vis. Exp. (2017).This video demonstrates the preparation of aldehyde-fixed non-human primate brain tissue using pre-embedding immunohistochemistry for electron microscopy. It outlines the steps for immunolabeling a specific neuronal protein, followed by a peroxidase reaction that produces a colored precipitate, enabling visualization of the target...
08:06
Y-27632 Enriches the Yield of Human Melanocytes from Adult Skin Tissues
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Cited by 3 •
2020
This paper reports that the addition of Y-27632 to TIVA medium can significantly increase the yield of melanocytes from adult skin tissues.
FAQs
Cell adhesion, cell-to-cell communication, and extracellular-matrix interactions jointly organize human tissue. Adhesion helps maintain relationships among neighboring cells, while communication coordinates their behavior; the matrix provides an interacting framework that influences tissue properties. Together, these mechanisms help determine whether tissue is strong, elastic, capable of transport, or able to participate in repair.
Extracellular matrix composition matters because it contributes to the physical and functional behavior of tissue. Examining it alongside tissue architecture can reveal changes associated with disease and help explain altered strength, elasticity, transport, or repair. This combined structural and molecular perspective also supports evaluation of treatments intended to restore or replace damaged tissue.
Medical interpretation commonly considers epithelial, connective, muscle, and nervous tissues as distinct structural contexts. Their different organization and specialized roles provide a framework for relating tissue appearance and molecular composition to normal physiology or disease. Recognizing which category is affected helps connect observations in a specimen with questions about pathology, repair, transplantation, or treatment.
Architecture records how cells and extracellular components are arranged and interact. When that organization changes, associated alterations in tissue properties or molecular composition can provide evidence of disease progression. For medical research, comparing architecture with molecular findings helps investigators move beyond a purely cellular description and assess how disease affects tissue function and how therapies may alter the damaged state.
Medical tissue analysis focuses on architecture and molecular composition, interpreted in relation to tissue function and disease. Structural observations can be considered with properties such as strength, elasticity, transport, and repair, while molecular findings add information about underlying changes. This approach supports diagnosis and pathology by linking what tissue looks like with how disease may be progressing.
It provides a basis for understanding how tissue structure and composition relate to damage, repair, and replacement. In transplantation, this knowledge helps frame the challenge of restoring or replacing tissue; in wound healing, it focuses attention on repair-related properties and interactions. These applications connect fundamental tissue biology with medical efforts to recover function after injury or damage.
Tissue engineering applies knowledge of tissue architecture, molecular composition, and extracellular-matrix interactions to the goal of restoring or replacing damaged tissue. The relevant scientific question is not only whether cells are present, but whether their organization and surrounding matrix support appropriate properties and function. This makes tissue analysis important for designing and evaluating treatment strategies.