Human Visceral Fat
Human Visceral Fat - Related Videos
08:52
Immunomagnetic Separation of Fat Depot-specific Sca1high Adipose-derived Stem Cells (ASCs)
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Cited by 2 •
2016
We present the techniques required to isolate the stromal vascular fraction (SVF) from mouse inguinal (subcutaneous) and perigonadal (visceral) adipose tissue depots to assess their gene expression and collagenolytic activity. This method includes the enrichment of Sca1high adipose-derived stem cells (ASCs) using immunomagnetic cell separation.
06:11
An Efficient Method to Obtain Dedifferentiated Fat Cells
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Cited by 4 •
2016
We have modified the conditions for DFAT cell generation and provide herein information regarding the use of an improved growth medium for the production of these cells.
09:25
Transplantation Into the Mouse Ovarian Fat Pad
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Cited by 7 •
2016
We describe an ovarian fad pad transplantation assay suitable for studies of normal and transformed epithelia of the female reproductive tract. The mouse fat pad allows transplantation of large tissue fragments, is easily accessible for surgery and imaging, and provides the most favorable native environment for tissues of Müllerian origin.
08:14
A Microphysiologic Platform for Human Fat: Sandwiched White Adipose Tissue
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Cited by 7 •
2018
White adipose tissue (WAT) has critical deficiencies in its current primary culture models, hindering pharmacological development and metabolic studies. Here, we present a protocol to produce an adipose microphysiological system by sandwiching WAT between sheets of stromal cells. This construct provides a stable and adaptable platform for primary WAT culture.
06:41
Decellularizing Mammary Fat Pads: Deriving Extracellular Matrix Hydrogels from Mammary Fat Pads
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2023
This video describes a technique of deriving extracellular matrix hydrogels by decellularizing murine mammary fat pads following ex vivo irradiation for in vitro studies. This hydrogel helps to mimic the in vivo breast tissue environment post-radiation treatment to study tumor cell behavior.
FAQs
Blood released from abdominal visceral fat can enter the portal circulation, which carries substances directly toward the liver. This positioning allows free fatty acids, adipokines, and inflammatory signals from the tissue to influence liver metabolism. The mechanism helps explain why visceral fat is relevant to insulin resistance and other metabolic disturbances rather than representing only stored body energy.
Enlarged adipocytes can alter the signals released by visceral fat, including free fatty acids, adipokines, and inflammatory mediators. Once these substances reach metabolic tissues, they may disrupt normal regulation of glucose and lipid handling, contributing to insulin resistance. This cellular activity is why the metabolic condition of the tissue matters in addition to its measured amount.
Its activity connects abdominal fat accumulation with several processes involved in cardiometabolic disease. Visceral fat can influence liver metabolism and promote insulin resistance through circulating fatty acids, adipokines, and inflammatory signals. Consequently, its assessment can contribute to evaluation of risks associated with type 2 diabetes, fatty liver disease, hypertension, and broader cardiovascular health.
Common assessment approaches include waist measurements, imaging, and body-composition analysis. These methods provide ways to estimate or characterize the amount of visceral fat when evaluating obesity-related risk. The selected approach can also support follow-up over time, allowing clinicians or researchers to examine whether visceral fat changes alongside diet, physical activity, or weight-management interventions.
Repeated assessment can show whether an intervention is associated with a change in visceral fat, complementing broader observations of body composition and health. Diet, physical activity, and weight management are identified approaches for intervention monitoring. Tracking this tissue is useful because its amount and activity provide information related to metabolic and cardiovascular health, not merely body size.
Visceral fat research helps connect tissue-level activity with diseases examined in medicine. Its release of free fatty acids, adipokines, and inflammatory signals can influence liver metabolism and insulin resistance, providing context for studies of type 2 diabetes and fatty liver disease. The same work also informs investigation of hypertension and cardiometabolic prevention.