Left Hemidiaphragm Paralysis

Left hemidiaphragm paralysis is the loss of normal movement in the left half of the diaphragm, an important respiratory muscle that helps draw air into the lungs. It usually results from impaired function of the left phrenic nerve, causing the affected hemidiaphragm to remain elevated and move paradoxically upward during inspiration rather than descending. Some patients have no symptoms, whereas others develop exertional breathlessness, reduced lung capacity, or difficulty breathing when lying down. Evaluation commonly combines chest imaging, pulmonary function testing, and dynamic studies such as the fluoroscopic sniff test or diaphragm ultrasound. Identifying the underlying cause guides observation, treatment, or surgical intervention.

Left Hemidiaphragm Paralysis - Related Videos

Research

JoVE EoE - Assay Techniques

Fluorescent Reporter-Based Paralysis Assay: A Technique to Assess Age-Associated Progressive Formation of Polyglutamine Fluorescent Reporter and Associated Paralysis in Caenorhabditis elegans

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2025

This video demonstrates an in vivo imaging-based assay to determine proteostasis decline due to aging. The assay uses Caenorhabditis elegans expressing polyglutamine YFP-fusion protein in body wall muscles to measure the age-associated aggregation of polyglutamine and induction of proteotoxicity, leading to paralysis.

Single-stage Dynamic Reanimation of the Smile in Irreversible Facial Paralysis by Free Functional Muscle Transfer

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Cited by 17 •

2015

The use of the masseteric nerve as donor nerve represents a single-stage alternative to the criterion standard two-stage procedure of cross-facial nerve grafting and free muscle transfer in facial paralysis. We provide a detailed description to safely perform this technique with a gracilis muscle transfer and discuss indications and limitations.

Inducing Paralysis in a Mouse Model via Transfer of Aquaporin-4-Specific Th17 Cells

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2025

This video demonstrates the procedure of inducing paralysis by transferring activated Th17 cells targeting aquaporin-4 into a mouse model. In the central nervous system, the activated Th17 cells interact with aquaporin-4-expressing astrocytes, triggering an immune response that leads to tail and limb paralysis in the mouse.

Swimming-Induced Paralysis (SWIP) Assay: A Method to Quantify Dopamine-Mediated Locomotion in C. elegans

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2023

Here, we introduce an assay to measure SWIP, a behavioral phenotype of C. elegans that occurs during vigorous motion like swimming. The example protocol discusses both manual and automated analysis approaches.

Research

JoVE Journal - Immunology and Infection
Free Sample

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

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Cited by 10 •

2017

Here, we present a protocol to induce paralysis and opticospinal inflammation by transfer of aquaporin-4 (AQP4)-specific T cells from AQP4-/- mice into WT mice. In addition, we demonstrate how to use serial optical coherence tomography to monitor visual system dysfunction.

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