Mouse Rib Resection
Mouse Rib Resection - Related Videos
08:42
A Surgical Procedure for Resecting the Mouse Rib: A Model for Large-Scale Long Bone Repair
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Cited by 7 •
2015
The overall goal of this procedure is to successfully resect a portion of bone from the rib of a mouse. The procedure was developed as a model to study large-scale long bone repair.
06:57
Transaxillary First Rib Resection for Treatment of the Thoracic Outlet Syndrome
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Cited by 3 •
2020
Here, we present a protocol of the transaxillary resection of the first rib for treatment of thoracic outlet syndrome caused by compression of the brachial plexus, subclavian vein and artery.
03:58
Brain Tumor Resection in a Mouse Using a Minimally Invasive Resection System
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2025
Source: Alomari, S., et al. Implementation of Minimally Invasive Brain Tumor Resection in Rodents for High Viability Tissue Collection. J. Vis. Exp. (2022)This video demonstrates the use of a minimally invasive resection system (MIRS) to excise tumor tissue from an anesthetized mouse implanted with a tumor. The procedure involves securing the mouse onto a stereotactic frame, reopening the previous surgical site to access the brain, and inserting a specialized cannula that utilizes suction and a...
06:08
Apical Resection Mouse Model to Study Early Mammalian Heart Regeneration
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Cited by 12 •
2016
A step-by-step video protocol of apical resection is demonstrated in this study. Apical resection is a recently highlighted surgical approach in mammalian heart regeneration research. This study may promote the application of apical resection as a standard methodology in research into the mechanism underlying heart regeneration.
03:58
Apical Resection Neonatal Mouse Model: A Surgical Procedure to Amputate the Ventricular Apex to Study Regenerative Potential in a Neonate Mouse Heart
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2025
In this video, we demonstrate the procedure to surgically remove the left ventricular apex of a neonatal mouse heart.
FAQs
The extent of resection determines the experimental purpose. Removing part of a rib can create a defined chest-wall injury, whereas removing all of the selected rib may provide broader access to the thoracic cavity. Keeping the selected rib and amount consistent helps researchers compare bone healing, regeneration, inflammation, or pain outcomes across animals.
Mouse rib resection creates a localized skeletal and chest-wall perturbation rather than an uncontrolled injury. That controlled change allows investigators to examine how bone and surrounding tissues respond, including healing and regeneration. The same model can also support evaluation of inflammatory and pain-related responses, linking structural injury with clinically relevant outcomes.
Standardization affects both scientific comparison and animal welfare. Consistent exposure of the selected rib, use of sterile instruments, controlled cutting, and reproducible wound closure reduce procedural variation. Careful respiratory and postoperative monitoring then helps identify differences attributable to the experimental condition rather than inconsistent surgery or inadequate recovery support.
A typical workflow begins after anesthesia with exposure of the selected rib through an incision. Researchers then separate surrounding tissue, cut the rib with sterile instruments, and close the wound. Respiratory and postoperative monitoring follows. Keeping these stages ordered helps preserve controlled access or injury while supporting recovery.
Respiratory monitoring is particularly important because the operation concerns the chest wall and may provide access to the thoracic cavity. Postoperative monitoring extends attention beyond the closure itself, helping researchers support recovery and maintain animal welfare. These observations are also part of a reproducible protocol, since recovery conditions can influence study outcomes.
Researchers may select mouse rib resection when a study requires either a reproducible chest-wall injury model or controlled experimental access to thoracic structures. Its applications include investigations of bone healing, tissue regeneration, inflammation, pain, and thoracic anatomy. The appropriate use depends on whether the study prioritizes injury response, anatomical access, or both.