Neurological Injury

Neurological injury is damage to the brain, spinal cord, or peripheral nerves that disrupts sensation, movement, cognition, or autonomic function and can produce lasting disability. It may result from trauma, stroke, infection, tumors, or toxic and metabolic conditions; after the initial insult, inflammation, excitotoxicity, impaired blood flow, and cellular swelling can extend tissue damage. In medicine, clinicians combine neurological examination with imaging and functional assessments to identify affected structures, estimate severity, and guide urgent care. Research on neuroprotection, neural repair, and rehabilitation seeks to limit secondary injury, restore function, and improve long-term outcomes.

Neurological Injury - Related Videos

Research

JoVE Journal - Neuroscience

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

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Cited by 21 •

2016

An optimized testing protocol is presented in this paper for the Rotarod performance test, used for measuring progressive neurological disability in TMEV-infected mice.

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury

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Cited by 15 •

2017

Athletes absorb several hundred mild traumatic brain injuries (mTBI)/concussions every year; however, the consequence of these on the brain is poorly understood. Therefore, an animal model of single and repetitive mTBI that consistently replicates clinically relevant symptoms provides the means to advance the study of mTBI and concussion.

Lipidomics and Transcriptomics in Neurological Diseases

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Cited by 13 •

2022

This article presents a modular protocol for tissue lipidomics and transcriptomics, and plasma lipidomics in neurological disease mouse models targeting lipids underlying inflammation and neuronal activity, membrane lipids, downstream messengers, and mRNA-encoding enzymes/receptors underlying lipid function. Sampling, sample processing, extraction, and quantification procedures are outlined.

Research

JoVE Journal - Medicine
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Controlled Cervical Laceration Injury in Mice

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Cited by 17 •

2013

A novel technique to create a reproducible in vivo model of cervical spinal cord laceration injury in the mouse is described. This technique is based on spine stabilization by fixation of the cervical facets and laceration of the spinal cord using an oscillating blade with an accuracy of ±0.01 mm.

Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram

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Cited by 5 •

2018

The article describes a practical method for recording horizontal eye movements with high accuracy by electro-oculogram in neurological patients, using a cup Ag-AgCl electrode with a wide plastic fringe. Stable measurement requires proper selection and fixation of electrodes, taking sufficient time for light adaptation to occur, and re-calibration as needed.

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