Non-ionizing Imaging
Non-ionizing Imaging - Related Videos
06:21
Imaging of Biological Tissues by Desorption Electrospray Ionization Mass Spectrometry
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Cited by 21 •
2013
Desorption electrospray ionization mass spectrometry (DESI-MS) is an ambient method by which samples, including biological tissues, can be imaged with minimal sample preparation. By rastering the sample below the ionization probe, this spray-based technique provides sufficient spatial resolution to discern molecular features of interest within tissue sections.
03:12
Ionization Energy
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2020
The amount of energy required to remove the most loosely bound electron from a gaseous atom in its ground state is called its first ionization energy (IE1). The first ionization energy for an element, X, is the energy required to form a cation with 1+ charge: The energy required to remove the second most loosely bound electron is called the second ionization energy (IE2). The energy required to remove the third electron is the third ionization energy, and so on. Energy is always required...
10:47
Whole-body Mass Spectrometry Imaging by Infrared Matrix-assisted Laser Desorption Electrospray Ionization (IR-MALDESI)
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Cited by 19 •
2016
A mass spectrometry imaging (MSI) source operated at atmospheric pressure was developed by coupling mid-infrared laser desorption and electrospray post-ionization. Exogenous ice matrix was used as the energy-absorbing matrix to facilitate resonant desorption of tissue-related material. This manuscript provides a step-by-step protocol for performing IR-MALDESI MSI of whole-body neonatal mouse.
09:38
Dithranol as a Matrix for Matrix Assisted Laser Desorption/Ionization Imaging on a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer
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Cited by 3 •
2013
Dithranol (DT; 1,8-dihydroxy-9,10-dihydroanthracen-9-one) has previously been reported as a MALDI matrix for tissue imaging of small molecules; protocols for the use of DT for the MALDI imaging of endogenous lipids on the surface of tissue sections by positive-ion MALDI-MS on an ultrahigh-resolution quadrupole-FTICR instrument are provided here.
07:31
Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator
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Cited by 2 •
2014
A growing number of radiation therapy devices offer the advantage of delivering the dose through very small beams to the tumor, allowing for increased conformity and higher doses per fraction. Many different detectors can be used for the dosimetry of these small fields. In the present study, the effect of ion recombination is investigated for a liquid ionization chamber using a stereotactic radiation therapy system.
FAQs
Ultrasound forms images by transmitting high-frequency sound waves and analyzing the echoes that return from internal structures. Differences in the returning signals create image information without requiring the magnetic fields used by MRI or the light used by optical systems. This mechanism makes ultrasound relevant for assessing soft tissues, blood flow, fetal development, and image-guided procedures.
MRI generates signals through a coordinated interaction between strong magnetic fields and radiofrequency pulses. These signals arise from atomic nuclei and are converted into images, providing a contrast mechanism distinct from ultrasound echoes and optical light. In medicine, that distinction helps MRI complement other non-ionizing modalities when evaluating soft tissues or tracking disease progression.
Optical non-ionizing imaging uses visible or near-infrared light to produce images. Its signal source therefore differs from both returning sound echoes and MRI signals from atomic nuclei. This approach broadens the available medical imaging options by adding light-based information to the acoustic and magnetic mechanisms provided by ultrasound and MRI.
Choosing among these methods depends on the information needed and the tissue or process being examined. Ultrasound, MRI, and optical systems use different physical inputs and generate different contrast mechanisms. Because no single approach provides every type of information, non-ionizing imaging complements computed tomography and other ionizing techniques rather than simply replacing them.
These techniques can support assessment of soft tissues, blood flow, fetal development, and disease progression. They can also produce images for image-guided procedures, extending their role beyond one-time diagnosis. The modality selected depends on which clinical question is being addressed and on whether anatomical or functional information is most relevant.
Repeated monitoring is a major clinical use because these techniques do not use ionizing radiation. Serial imaging can help clinicians follow disease progression, while the same safety profile supports ongoing assessment when imaging is needed more than once. Non-ionizing methods can therefore contribute to diagnosis, follow-up, and image-guided care across medical settings.