Sample Holder Design

Sample holder design is the engineering of containers or supports that secure, position, and protect specimens during laboratory measurement, processing, or imaging, making reliable data possible. It works by matching holder geometry, materials, and access points to the sample and instrument so the specimen remains stable, correctly aligned, uncontaminated, and exposed to the intended measurement conditions. In medicine, thoughtful designs can accommodate fluids, tissues, or cells while limiting handling errors and preserving sample integrity. The resulting holders support reproducible microscopy, spectroscopy, diagnostic testing, and biomedical research, while enabling safer workflows and adaptation to increasingly specialized analytical instruments.

Sample Holder Design - Related Videos

Research

JoVE Journal - Biochemistry
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An All-in-one Sample Holder for Macromolecular X-ray Crystallography with Minimal Background Scattering

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Cited by 4 •

2019

A novel sample holder for macromolecular X-ray crystallography along with a suitable handling protocol is presented. The system allows crystal growth, crystal soaking and in situ diffraction data collection at both, ambient and cryogenic temperature without the need of any crystal manipulation or mounting.

Education

JoVE Business - Marketing

Sample Design

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2024

Effective sampling is crucial for ensuring that research results are accurate and applicable. The process starts by identifying the target population, such as regular coffee shop visitors interested in trying new drinks. Clearly defining this group helps focus the study on gathering relevant data from the right people. The next step involves creating a sampling frame, which is a detailed and current list of everyone in the target group. An accurate sampling frame is essential to avoid missing...

Research

JoVE Journal - Engineering
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Design and Use of a Full Flow Sampling System (FFS) for the Quantification of Methane Emissions

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Cited by 13 •

2016

We have designed, developed, and implemented a novel full flow sampling system (FFS) for quantification of methane emissions and greenhouse gases from across the natural gas supply chain.

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

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2025

This protocol provides a method for the systematic global optimization of genetically encoded biosensors through automation-assisted genetic library generation and assessment. This is coupled with design-of-experiment methodologies to streamline experimentation and enable the selection of genetic components to tune biosensors to specific design outcomes.

Group Design

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2020

The most basic experimental design involves two groups: the experimental group and the control group. The two groups are designed to be the same except for one difference— experimental manipulation. The experimental group gets the experimental manipulation—that is, the treatment or variable being tested—and the control group does not. Since experimental manipulation is the only difference between the experimental and control groups, we can be sure that any differences between the two are due to...

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