Sham Thoracotomy
Sham Thoracotomy - Related Videos
09:11
Cell-based Therapy for Heart Failure in Rat: Double Thoracotomy for Myocardial Infarction and Epicardial Implantation of Cells and Biomatrix
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Cited by 8 •
2014
Implantation of a biograft to treat myocardial infarction induced by LAD ligation in a rodent model has conventionally required two open-heart surgeries. In order to reduce mortality and provide optimal conditions for fixation of solid and gelatinous biomatrices associated with cells, minimally invasive procedures have been developed.
04:43
Endotracheal Intubation via Tracheotomy and Subsequent Thoracotomy in Rats for Non-Survival Applications
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2024
Here we introduce a standardized procedure for endotracheal intubation via tracheotomy followed by thoracotomy in rats, aimed at enhancing the precision and reproducibility of non-survival applications requiring invasive ventilation and exposure of thoracic organs in in vivo rat models.
08:50
Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
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Cited by 6 •
2018
The goal of this protocol is to describe in detail the technique of minimally invasive aortic valve replacement through a right anterior mini-thoracotomy and central aortic cannulation. This technique can potentially enhance patients' comfort and, by reducing post-operative morbidity, promote lowering the length of stay and global costs.
08:33
A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers
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Cited by 2 •
2024
The current study is a randomized, placebo-controlled trial to determine the efficacy of cranial electrical stimulation (CES) for improving pain and function in fibromyalgia and further develop resting functional connectivity magnetic resonance imaging (rs-fcMRI) as a clinical tool to assess the neural correlates and mechanisms of chronic pain and analgesic response.
09:22
Mouse Pneumonectomy Model of Compensatory Lung Growth
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Cited by 14 •
2014
Mouse pneumonectomy is a commonly employed model of compensatory lung growth. This procedure can be used in conjunction with lineage tracing or transgenic mouse models to elucidate underlying mechanisms.
FAQs
The comparison is designed to hold much of the surgical experience constant while omitting the intervention being tested. Similar anesthesia, incision, closure, and perioperative care can account for changes caused by recovery, surgical attention, or placebo responses. If outcomes differ between groups, the findings more specifically support an effect from the investigational treatment rather than from the operation alone.
Comparable perioperative care strengthens the study’s internal comparison by reducing differences unrelated to the intervention. Anesthesia, chest incision, closure, and other associated care can influence participants’ experiences and recovery. Keeping these elements similar helps investigators evaluate whether the added therapeutic procedure, rather than unequal surgical management, explains any observed difference in outcomes.
Omitting the therapeutic component creates a control condition that preserves the experience of undergoing an operation without delivering the treatment under investigation. This separation allows investigators to examine treatment-specific benefit against changes associated with surgery, placebo responses, and recovery. The design is therefore especially relevant when assessing whether a new surgical or device-based intervention adds meaningful value.
Credibility depends on matching important aspects of the operative experience while withholding only the therapeutic procedure. The study must account for anesthesia, incision, closure, and comparable perioperative care, so these features do not systematically favor one group. A strong scientific justification is also necessary because the control exposes participants to procedural risks without direct therapeutic intent.
Participants may receive anesthesia, undergo a chest incision, have the incision closed, and receive perioperative care comparable to that provided in the treatment group. The therapeutic procedure itself is omitted. These elements reproduce key parts of the operative experience for comparison, while the study team must still consider and minimize the risks associated with the simulated procedure.
Researchers may consider this design when evaluating a new surgical or device-based treatment and when outcomes could also reflect the operation itself. By comparing the investigational procedure with a simulated operative experience, they can assess whether benefits exceed those associated with surgical care. Its use requires a strong scientific rationale because participants undergo procedural risks without direct therapeutic intent.
Because participants may face anesthesia, incision, and other procedural risks without receiving the therapeutic procedure, the study requires rigorous ethical review and careful risk minimization. Informed consent must clearly address the simulated nature of the operation and its risks. Investigators also need strong scientific justification to show that the question cannot be adequately addressed with a less burdensome design.
A greater benefit in the treatment group would support the possibility that the investigational procedure contributes effects beyond those associated with surgery, placebo responses, or recovery. The comparison does not eliminate the need for careful interpretation, but it helps separate treatment-specific outcomes from changes that may occur after comparable perioperative care alone.