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Cell-based Therapy for Heart Failure in Rat: Double Thoracotomy for Myocardial Infarction and Epicardial Implantation of Cells and Biomatrix
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Chapters
- 00:05Title
- 01:15Mesenchymal Stem Cell Isolation from Bone Marrow Protocol
- 02:41First Thoracotomy and Ligation of Left Anterior Descending Coronary Artery
- 05:19Epicardial Administration of the Treatment Via a Second Thoracotomy
- 06:50Results: Procedure Illustation and Post-operative Evaluation
- 08:40Conclusion
Implantation of a biograft to treat myocardial infarction induced by LAD ligation in a rodent model has conventionally required two open-heart surgeries. In order to reduce mortality and provide optimal conditions for fixation of solid and gelatinous biomatrices associated with cells, minimally invasive procedures have been developed.
