Spinal Anesthesia

Spinal anesthesia is a regional anesthetic technique that temporarily eliminates sensation and movement in the lower body while the patient remains conscious, making it important for many surgical procedures. It works by injecting a local anesthetic into the cerebrospinal fluid within the subarachnoid space, where the drug blocks voltage-gated sodium channels in spinal nerve fibers and interrupts sensory, motor, and autonomic nerve transmission. Clinicians use spinal anesthesia for operations involving the lower abdomen, pelvis, perineum, and lower limbs, including cesarean delivery. Its targeted effect can reduce the need for general anesthesia, while careful dosing and monitoring help manage effects such as low blood pressure, urinary retention, or headache.

Spinal Anesthesia - Related Videos

Education

JoVE Core - Pharmacology

Local Anesthetics: Clinical Application as Spinal Anesthesia

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2023

Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...

Research

JoVE Journal - Medicine

Spinal Sonography for Ultrasound-Guided Lumbar Neuraxial Anesthesia

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2025

The protocol described here provides the basics of spine sonoanatomy and a quick, straightforward method for performing ultrasound-guided neuraxial anesthesia. Additionally, two handheld devices that enhance portability are presented, one of which uses pattern recognition software to aid in epidural space localization.

Anesthesia Induction and Maintenance

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2016

Source: Kay Stewart, RVT, RLATG, CMAR; Valerie A. Schroeder, RVT, RLATG. University of Notre Dame, IN The Guide for the Care and Use of Laboratory Animals ("The Guide") states that pain assessment and alleviation are integral components of the veterinary care of laboratory animals. The definition of anesthesia is the loss of feeling or sensation. It is a dynamic event involving changes in anesthetic depth with respect to an animal's metabolism, surgical stimulation, or variations in the...

Anesthesia and Monitoring in a Rabbit Model

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2026

All animal procedures described here must be conducted in accordance with institutional animal ethics guidelines and approved by IACUC. All procedures must follow the principles of the 3Rs—Replacement, Reduction, and Refinement—and must be performed by trained personnel. Anesthesia is an essential component of rabbit surgical and experimental procedures because it prevents pain, reduces stress responses, and helps immobilize the animal during handling and manipulation when general anesthesia is...

Anesthesia and Monitoring in a Pig Model

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2026

All animal procedures described here must be conducted in accordance with institutional animal ethics guidelines and approved by IACUC. All procedures must follow the principles of the 3Rs—Replacement, Reduction, and Refinement—and must be performed by trained personnel. Pigs are commonly used in biomedical and surgical research because of their anatomical and physiological similarities to humans. During procedures, anesthesia prevents pain, reduces stress, limits movement, and supports animal...

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