Thromboembolic Disease
Thromboembolic Disease - Related Videos
06:38
The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo
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2025
To simulate thromboembolic stroke, emboli prepared from heterologous rat blood were injected into the middle cerebral artery, followed by administration of systemic thrombolysis for recanalization. This version of the model is optimized for use in a multi-laboratory network and supports testing multiple candidate therapeutics.
09:22
Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
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Cited by 22 •
2015
Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and Right Ventricular (RV) dysfunction were induced in piglets by progressive obstruction of the pulmonary arteries. Consequences were remarkably similar to those observed in CTEPH patients. This animal model would be a very useful tool for pathophysiology and therapeutic experiments on CTEPH and RV failure.
07:41
Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
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Cited by 2 •
2022
We present a protocol to induce and phenotype an acute right heart failure in a large animal model with chronic pulmonary hypertension. This model can be used to test therapeutic interventions, to develop right heart metrics or to improve the understanding of acute right heart failure pathophysiology.
10:47
An Overview of Genetics and Disease
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2023
Many human diseases are associated with mutations or variations in genetic sequences. Some of these genetic variants are heritable, passed down from generation to generation, while others arise sporadically during an organism’s life and cause diseases such as cancer. Researchers are trying to identify and characterize these genetic alterations in the hopes of improving diagnosis and therapeutic options for patients.In this video, we will examine the history of genetic disease research, and...
09:23
Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model
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Cited by 12 •
2012
The inoculation of Trypanosoma cruzi in fertile eggs prior to incubation renders the parasite kDNA minicircle integration in embryo cells genome. Crossbreeding reveals the vertical transfer of the mutations to progeny. The kDNA integrates into coding regions at several chromosomes and the chickens die with an inflammatory autoimmune heart disease.
FAQs
A thrombus developing in a deep vein may detach, becoming an embolus that moves through circulation. If it reaches the pulmonary arteries, it can obstruct blood flow through the lungs and damage tissue. This pathway explains why clinicians consider both the original venous clot and the possibility of downstream pulmonary consequences when evaluating the disease.
When arterial circulation is obstructed, the consequences differ from those of a venous clot traveling to the lungs. Reduced arterial blood flow can contribute to ischemic stroke or limb injury, linking the location of obstruction to the organ at risk. This distinction helps clinicians interpret thromboembolic disease according to the circulation involved and the tissue threatened.
Initial clot management addresses the current obstruction, but care also aims to reduce recurrence, organ damage, and death. Prevention is therefore not separate from treatment planning: clinicians must consider how the disease may continue to threaten circulation after the immediate event. This goal supports preventive measures and individualized treatment rather than a single uniform approach.
Risk prediction can help identify how likely clinically important thromboembolic events or recurrence may be, while individualized treatment adapts care to the patient’s circumstances. The overview identifies both areas as active research priorities. Better prediction and personalization are intended to improve diagnostic decisions, treatment selection, and prevention of serious outcomes.
Evaluation begins with clinical assessment and is supported by imaging. Together, these approaches help clinicians investigate whether a clot-related process is affecting the circulation and whether an important site, such as the pulmonary arteries, may be involved. Their role is to guide subsequent decisions about anticoagulant therapy, clot removal, and preventive care.
Anticoagulant therapy and clot removal are identified as treatment approaches that can help reduce recurrence, organ damage, and death. They should be understood alongside clinical assessment and imaging, because management depends on recognizing the clot-related problem and its location. Together with preventive measures, these options form part of medical management.
More effective diagnosis could help clinicians recognize clot-related disease and guide decisions about treatment and prevention. The overview places diagnostic improvement alongside better risk prediction and individualized treatment as an ongoing research focus. These priorities seek to reduce recurrence, organ damage, and death across venous and arterial presentations.