Transcutaneous Ultrasound Bio-microscopy
Transcutaneous Ultrasound Bio-microscopy - Related Videos
06:27
Transcutaneous Microcirculatory Imaging in Preterm Neonates
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Cited by 6 •
2015
Microcirculatory imaging (MI) is used to monitor peripheral perfusion in critically ill or preterm neonates. This manuscript and video demonstrates the optimal approach for obtaining high-quality images.
07:18
Transcutaneous Assessment of Renal Function in Conscious Rodents
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Cited by 34 •
2016
Determination of glomerular filtration rate (GFR) is the gold standard to assess overall kidney function. However, traditional procedures to measure this parameter are cumbersome and require a large investment of time. Here we describe a faster and minimally invasive method to determinate GFR transcutaneously.
04:42
Transcutaneous Auricular Vagus Nerve Stimulation on the Human Ear
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2025
Source: Badran, B. W., et al. Laboratory Administration of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS): Technique, Targeting, and Considerations. J. Vis. Exp. (2019)This video demonstrates transcutaneous auricular vagus nerve stimulation (taVNS), a noninvasive method for modulating brain activity. Electrodes are placed on the anterior wall of the outer ear canal and the tragus, targeting the auricular branch of the vagus nerve (ABVN). When stimulated, the resulting nerve impulse...
10:36
Ultrasound Localization Microscopy for Super-Resolution Mapping of the Rodent Brain Microvasculature
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2025
Ultrasound Localization Microscopy (ULM) is a recently developed technique that allows for an unprecedented level of resolution in imaging the microvasculature in vivo. In this work, we describe in detail how to obtain super-resolved images of the brain microvasculature in rodents using a standardized functional ultrasound imaging platform designed for preclinical research.
16:38
Bridging the Bio-Electronic Interface with Biofabrication
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Cited by 3 •
2012
This article describes a biofabrication approach: deposition of stimuli-responsive polysaccharides in the presence of biased electrodes to create biocompatible films which can be functionalized with cells or proteins. We demonstrate a bench-top strategy for the generation of the films as well as their basic uses for creating interactive biofunctionalized surfaces for lab-on-a-chip applications.
FAQs
The transducer’s frequency sets a practical balance between image detail and penetration. Higher frequencies can distinguish structures that are closer together, producing improved spatial resolution, but their useful imaging depth is limited. Consequently, transcutaneous ultrasound biomicroscopy is most informative when the tissue or lesion of interest lies near the skin surface.
Returning echoes arise from interfaces between tissues and are converted by the imaging system into cross-sectional structural information. Differences in these echoes help reveal the arrangement of superficial layers and localized abnormalities. Because the system acquires this information in real time, investigators can examine tissue structure dynamically rather than relying only on a fixed specimen.
Transcutaneous ultrasound biomicroscopy can provide structural information without surgical sampling or ionizing radiation. That combination supports repeated assessment of superficial tissues while avoiding the need to remove tissue for every observation. Its value is therefore strongest when researchers or clinicians need noninvasive visualization for investigation, evaluation, or follow-up of accessible tissue changes.
The method is suited to structures close enough to the skin for high-frequency ultrasound to reach them effectively. Relevant targets include skin layers, subcutaneous structures, small lesions, and other superficial tissue changes. Deeper targets become less suitable as the frequency required for near-microscopic detail limits imaging depth.
An examination can generate detailed cross-sectional views of superficial tissue organization and reveal changes in layers, subcutaneous structures, or small lesions. The resulting structural information may support assessment of a localized abnormality, help characterize tissue changes, and provide a real-time basis for observing superficial anatomy during medical research or evaluation.
Its real-time structural imaging allows superficial tissues to be examined repeatedly without surgical sampling or ionizing radiation. Serial observations can therefore help document tissue changes during a treatment-related investigation, provided the relevant structures remain within the technique’s effective imaging depth. This makes the method useful for tracking structural responses in accessible tissues.
In medical research, the approach can contribute to studies of superficial tissue disease by supplying near-microscopic structural observations. It may also support development of models for superficial tissue disease, where visualizing layers, lesions, and tissue changes helps connect model findings with measurable anatomy. These applications extend its use beyond a single clinical assessment.