Cardiac Diastole
Cardiac Diastole - Related Videos
11:04
Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
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Cited by 8 •
2014
Accurate, causality-based quantification of global diastolic function has been achieved by kinematic modeling-based analysis of transmitral flow via the Parametrized Diastolic Filling (PDF) formalism. PDF generates unique stiffness, relaxation, and load parameters and elucidates 'new' physiology while providing sensitive and specific indexes of dysfunction.
15:45
Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice
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Cited by 11 •
2013
We describe the protocol to perform a cardiac stress test induced by dobutamine and monitored by cardiac catheterization in normal mice. Also we show its application to unmask subclinical cardiac disease in high fat diet-induced obese mice.
10:22
Echocardiographic and Histological Examination of Cardiac Morphology in the Mouse
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Cited by 29 •
2017
Echocardiographic examination is frequently used in mice. Expensive high-resolution ultrasound devices have been developed for this purpose. This protocol describes an affordable echocardiographic procedure combined with histological morphometric analyses to determine cardiac morphology.
10:51
Cardiac Exam III: Abnormal Heart Sounds
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2023
Source: Suneel Dhand, MD, Attending Physician, Internal Medicine, Beth Israel Deaconess Medical Center Having a fundamental understanding of normal heart sounds is the first step toward distinguishing the normal from the abnormal. Murmurs are sounds that represent turbulent and abnormal blood flow across a heart valve. They are caused either by stenosis (valve area too narrow) or regurgitation (backflow of blood across the valve) and are commonly heard as a "swishing" sound during auscultation.
11:37
Cardiac Magnetic Resonance Imaging
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2023
Source: Frederick W. Damen and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana In this video, high field, small-bore magnetic resonance imaging (MRI) with physiological monitoring is demonstrated to acquire gated cine loops of the murine cardiovascular system. This procedure provides a basis for assessing left-ventricular function, visualizing vascular networks, and quantifying motion of organs due to respiration. Comparable small animal...
FAQs
The key mechanical transition is the fall in ventricular pressure after systole. Once ventricular pressure becomes low enough, the atrioventricular valves open, allowing blood to move from the atria into the ventricles. This pressure-dependent valve behavior determines whether filling can proceed effectively and links ventricular relaxation to the volume available for the next contraction.
Atrial contraction supplies the final contribution to ventricular filling, after blood has already moved from the atria into the ventricles. This late input is therefore a distinct part of the filling sequence rather than the entire mechanism. In analyses of Cardiac Diastole, separating earlier flow from the atrial contribution helps relate chamber events to overall ventricular filling.
The coronary arteries receive much of their blood supply during the heart’s relaxation phase. This makes diastolic timing important not only for filling the ventricles but also for supporting blood delivery to the heart muscle itself. Consequently, studies of Cardiac Diastole can connect ventricular relaxation with the circulation that sustains cardiac tissue.
Autonomic neural signals can alter heart rate, ventricular relaxation, and ventricular filling. These effects provide a direct link between nervous-system activity and the mechanical events occurring during Cardiac Diastole. In neuroscience, examining that link helps clarify how brain-heart regulation operates and how its disruption may be relevant to health and disease.
Neuroscience applications focus on relationships among autonomic neural signals, heart rate, relaxation, and ventricular filling. Cardiac Diastole provides the cardiac context in which these variables can be considered together rather than as isolated processes. This approach helps investigators study brain-heart regulation and its relevance across both normal physiology and disease-related changes.
Changes in autonomic neural signaling may modify heart rate, the degree of ventricular relaxation, or the amount of ventricular filling. Interpreting these variables together helps researchers determine how neural regulation is reflected in cardiac performance. The approach is particularly relevant when comparing brain-heart function in health with patterns associated with disease.