Endolymphatic Sac Obliteration

Endolymphatic Sac Obliteration is a specialized otologic microsurgical procedure that alters the inner ear’s endolymphatic system, which helps regulate fluid volume and pressure involved in hearing and balance. During surgery, the endolymphatic sac, and sometimes its associated duct, is exposed and sealed or packed, interrupting fluid exchange and modifying endolymph dynamics. The technique has been used for medically refractory Ménière’s disease, particularly when recurrent vertigo persists despite conservative treatment. Its intended outcome is improved vertigo control, although effects on hearing and tinnitus vary, and potential complications include hearing loss, disequilibrium, and injury to nearby structures.

Endolymphatic Sac Obliteration - Related Videos

Research

JoVE Journal - Biology

Surgical Induction of Endolymphatic Hydrops by Obliteration of the Endolymphatic Duct

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Cited by 12 •

2010

This video shows how to surgically obstruct the guinea pig's endolymphatic duct to produce endolymphatic hydrops.

Research

JoVE Journal - Biology
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Dissection of the Endolymphatic Sac from Mice

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Cited by 5 •

2021

This study describes how to dissect the endolymphatic sac from the inner ear of the mouse at different ages. The result of a similar dissection is shown in an Slc26a4-null mouse model of enlargement of the endolymphatic sac. A transgenic mouse with a fluorescent reporter expressed in the endolymphatic sac is presented as a model to readily visualize the endolymphatic sac, and educational tool.

Surgical Treatment of an Endolymphatic Sac Tumor

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Cited by 1 •

2023

Here, we discuss clinical and radiological features of endolymphatic sac tumors and report the methodology and results of a surgical removal in a case in care at our otologic referral center.

A Revised Surgical Approach to Induce Endolymphatic Hydrops in the Guinea Pig

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Cited by 6 •

2020

This article demonstrates an extradural approach to obliterate the guinea pig endolymphatic sac and injure the endolymphatic duct with a fine pick in order to induce experimental endolymphatic hydrops.

Isolation of Early Hematopoietic Stem Cells from Murine Yolk Sac and AGM

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Cited by 19 •

2008

This video shows how to micro-dissect the yolk sac and aorta-gonad-mesonephros region from embryos and use flow cytometry to sort hematopoietic stem cells.

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