Posterior Segment

The posterior segment is the portion of the eye located behind the lens, comprising the vitreous body, retina, choroid, and optic nerve; it is essential for visual perception and retinal health. Light reaches the retina through the vitreous, where photoreceptors convert it into neural signals that are processed by retinal circuits and transmitted through the optic nerve to the brain. In neuroscience, studying this region clarifies how sensory information is encoded and how retinal neurons connect with central visual pathways. Posterior-segment examination and imaging also support research and diagnosis of retinal degeneration, vascular disorders, inflammation, and optic-nerve disease.

Posterior Segment - Related Videos

Research

JoVE EoE - Large Animal Models

Isolating Short Posterior Ciliary Arteries: A Protocol to Excise Intact Short Posterior Ciliary Microvessels from Porcine Eye

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2025

This video describes the protocol to isolate the short posterior ciliary arteries from the porcine eye. The isolated short posterior arteries are a suitable source for elucidating the molecular insights and protein profiles of the ocular blood vessels.

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

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Cited by 3 •

2020

We describe and detail the use of the translaminar autonomous system. This system utilizes the human posterior segment to independently regulate the pressure inside the segment (intraocular) and surrounding the optic nerve (intracranial) to generate a translaminar pressure gradient that mimics features of glaucomatous optic neuropathy.

Anterior Eye Segment Dissection: A Method to Isolate Cornea Bearing Anterior Segment from Porcine Eye

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2025

In this video, we demonstrate the dissection of the cornea-bearing anterior segment of the porcine eye. The isolated segment can be used for organ culturing to study the pathophysiology of eye disorders.

A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures

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Cited by 33 •

2014

The present work provides a comprehensive set of guidelines for manually tracing the medial temporal lobe (MTL) structures. This protocol can be applied to research involving structural and/or combined structural-functional magnetic resonance imaging (MRI) investigations of the MTL, in both healthy and clinical groups.

Research

JoVE Journal - Biology
Free Sample

Volume Segmentation and Analysis of Biological Materials Using SuRVoS (Super-region Volume Segmentation) Workbench

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Cited by 10 •

2017

Segmentation of three-dimensional data from many imaging techniques is a major bottleneck in analysis of complex biological systems. Here, we describe the use of SuRVoS Workbench to semi-automatically segment volumetric data at various length-scales using example datasets from cryo-electron tomography, cryo soft X-ray tomography, and phase contrast X-ray tomography techniques.

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