Risky Options

Risky options are choices whose outcomes are uncertain, requiring people or animals to weigh possible rewards against probabilities and potential losses. In neuroscience, researchers examine how the brain represents these alternatives through interactions among valuation systems, the prefrontal cortex, striatum, and dopamine signaling, which integrate expected value, uncertainty, and prior experience to guide behavior. Studying risky choice helps explain decision-making, learning, and self-control, while revealing how stress, addiction, psychiatric disorders, and neurological injury can alter sensitivity to reward or loss. Experimental tasks involving probabilistic gains and losses provide measurable models of these processes for basic and clinical research.

Risky Options - Related Videos

Research

JoVE Journal - Neuroscience

Measuring the Subjective Value of Risky and Ambiguous Options using Experimental Economics and Functional MRI Methods

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Cited by 19 •

2012

Using functional MRI and behavioral methods to determine the neural representation of the subjective value of risky and ambiguous options in the human brain.

Research

JoVE Journal - Developmental Biology
Free Sample

Streamlined 3D Cerebellar Differentiation Protocol with Optional 2D Modification

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Cited by 12 •

2017

We describe a simplified 3D differentiation protocol for hPSCs, using defined medium and reduced growth factors, capable of generating cell aggregates with early neuroepithelial structures and positive for cerebellar-associated markers, as well as an optional 2D modification for differentiating cells as a monolayer to generate functional neurons.

Endolymphatic Duct Blockage as a Surgical Treatment Option for Ménière's Disease

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Cited by 1 •

2023

Endolymphatic duct blockage is a relatively new surgical method for patients suffering from Ménière's disease. Following a regular mastoidectomy, the endolymphatic duct is identified and ligated using a regular titanium hemoclip. The effectiveness of this procedure is currently being assessed in a randomized trial.

Plasma Polishing as a New Polishing Option to Reduce the Surface Roughness of Porous Titanium Alloy for 3D Printing

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Cited by 2 •

2023

Plasma polishing is a promising surface processing technology, especially suitable for 3D printing of porous titanium alloy workpieces. It can remove semi-molten powders and ablative oxide layers, thereby effectively reducing surface roughness and improving surface quality.

Novel Surgical Rodent Model for Studying Neuroma Pain Treatment Options using Targeted Muscle Reinnervation Through the Saphenous Nerve

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2025

This protocol presents a reproducible rat model using sensory nerves to mimic human neuroma pain and assess surgical treatments, offering a valuable tool for translational neuroma research.

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