Tumor Morphology Assessment
Tumor Morphology Assessment - Related Videos
03:07
Morphological and Physiological Monitoring of Tumor Spheroids Using Optical Coherence Tomography
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2025
Source: Huang, Y. et. al., Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography. J. Vis. Exp. (2019)This video demonstrates the use of optical coherence tomography (OCT) to monitor tumor spheroids in a multi-well plate by capturing high-resolution cross-sectional images. By analyzing light reflections from cellular structures, OCT constructs 3D models to assess morphological features like size and shape while also...
09:03
Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
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Cited by 7 •
2014
We describe a matrigel plug assay to illustrate angiogenic potential of a pool of factors secreted by cancer cells using two complementary imaging modalities, ultrasound and endomicroscopy. The matrigel, an extracellular matrix (ECM)-mimic gel, is utilized to introduce the host (mouse) with angiogenic factors secreted to the conditioned media...
04:11
DCE-MRI of Orthotopic Pancreatic Tumor Xenografts: A Method to Assess Microvasculature in a Target Tumor Tissue
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2023
This video describes the technique of DCE-MRI for orthotropic pancreatic tumor xenografts in mice. DCE-MRI is a non-invasive method to analyze microvasculature in a target tissue, and useful to assess vascular response in a tumor following a novel therapy. This method will assist investigators to apply DCE-MRI for orthotopic gastrointestinal cancer mouse models.
09:43
Functional and Morphological Assessment of Diaphragm Innervation by Phrenic Motor Neurons
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Cited by 16 •
2015
Compound muscle action potential recording quantitatively assesses functional diaphragm innervation by phrenic motor neurons. Whole-mount diaphragm immunohistochemistry assesses morphological innervation at individual neuromuscular junctions. The goal of this protocol is to demonstrate how these two powerful methodologies can be used in various rodent models of spinal cord disease.
04:13
A Technique to Assess the In Vivo Localization of Tumor-Specific Antibodies
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2025
This video demonstrates a technique to study the in vivo localization of tumor-specific antibodies in a mouse tumor xenograft model. Upon subcutaneously injecting cancer cells into mice for tumor formation, fluorescently-labeled antibodies are injected that bind to tumor-specific receptors, enabling in vivo assessment of antibody localization via imaging.
FAQs
Cellular features such as cell shape and nuclear appearance provide information about the individual elements within a lesion, while tissue organization shows how those elements are arranged collectively. Examining both levels gives a more complete picture than either alone, allowing investigators to relate microscopic structure to tumor behavior and to features associated with malignancy in central nervous system neoplasms.
Vascular patterns and the boundary between a tumor and surrounding brain tissue add structural context to the cellular findings. They can indicate how the lesion is organized within the brain and help identify features associated with malignancy. Evaluating these characteristics together supports more informed characterization of tumor structure and potential clinical significance.
Morphological observations provide a tissue-based perspective that can be correlated with molecular findings rather than considered in isolation. This comparison helps researchers and pathologists examine whether microscopic structure aligns with other biological information about a central nervous system neoplasm. The combined perspective supports tumor classification and research into behavior, treatment response, and prognosis.
The assessment uses histological staining followed by microscopy to examine the tumor’s cellular and tissue features. Observers evaluate cell shape, nuclear appearance, tissue organization, vascular patterns, and the interface with surrounding brain tissue. Recording these features systematically creates a structural profile that can support characterization, classification, and later correlation with clinical or molecular information.
Tumor morphology assessment is used when researchers or pathologists need to distinguish tumor types, identify features associated with malignancy, or support classification of central nervous system neoplasms. It also provides a basis for connecting microscopic findings with symptoms, molecular results, treatment response, and prognosis, making it relevant to both investigative studies and clinical evaluation.
Microscopic morphology can support diagnostic interpretation and tumor classification while documenting structural features that may carry clinical significance. Its value extends beyond naming a tumor: the findings can be correlated with symptoms, molecular characteristics, treatment response, and prognosis. These correlations help place tissue appearance within a broader understanding of disease behavior and patient relevance.