Metabolic Side Effects
Metabolic Side Effects - Related Videos
05:41
Metabolic Profile Analysis of Zebrafish Embryos
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Cited by 42 •
2013
Zebrafish represent a powerful vertebrate model that has been under-utilised for metabolic studies. Here we describe a rapid way to measure the in vivo metabolic profile of developing zebrafish that allows the comparison of different mitochondrial function parameters between genetically or pharmacologically manipulated embryos, thereby increasing the applicability of this organism.
00:52
What is Metabolism?
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2019
Overview Metabolism represents all of the chemical activity in a cell, including reactions that build molecules (anabolism) and those that break molecules down (catabolism). Anabolic reactions require energy, whereas catabolic reactions provide it. Thus, metabolism describes how cells transform energy through a variety of chemical reactions, which are often made more efficient with the help of enzymes. Metabolism Is the Sum of All of the Chemical Reactions That Take Place in an Organism
10:19
An Introduction to Cell Metabolism
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2023
In cells, critical molecules are either built by joining together individual units like amino acids or nucleotides, or broken down into smaller components. Respectively, the reactions responsible for this are referred to as anabolic and catabolic. These reactions require or produce energy typically in the form of a “high-energy” molecule called ATP. Together, these processes make up “Cell Metabolism,” and are hallmarks of healthy, living cells.JoVE’s introduction to cell metabolism briefly...
06:59
Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
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Cited by 7 •
2016
The goal of this protocol is to present a standard method to perform intravenous glucose tolerance tests (IVGTTs) to assess glycemic control in nonhuman primates and assess their metabolic status from healthy to dysmetabolic.
03:01
alamarBlue Assay: A Sensitive Fluorometric Method to Screen the Cytotoxic Effects of Artificial Tear Formulations on Metabolic Activity of Human Corneal Epithelial Cells
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2025
This video describes an in vitro fluorometric assay to assess the effects of artificial tear formulations on the cellular metabolic activity of corneal epithelial cells using resazurin-based Alamar blue solution. A non-toxic formulation maintains the cells in a healthy, metabolically active state, facilitating the reduction of resazurin into a highly fluorescent resorufin.
FAQs
The affected pathway often determines which metabolic outcome appears. Changes in hormone signaling or insulin sensitivity can shift glucose regulation, while altered appetite or energy handling may influence body weight. Effects on hepatic metabolism can modify lipid-related measures, and changes in renal handling of solutes can disturb electrolyte balance. Linking the pattern to its pathway helps pharmacologists interpret mechanism rather than treating every change as equivalent.
A dose increase or decrease can change the intensity of a drug’s influence on metabolic pathways, so a previously unnoticed effect may become measurable or a known effect may lessen. Changes can also develop during ongoing treatment, making timing important. Comparing metabolic findings with treatment history and dose changes helps researchers and clinicians identify evolving drug-related effects and recognize when closer assessment may be needed.
These effects do not represent a single physiological pattern. One medication-related change may be most evident in glucose regulation, another in lipids, electrolytes, or body weight, depending on the pathway affected. Hormonal, appetite-related, hepatic, and renal mechanisms therefore provide different pharmacological explanations. This distinction matters because the relevant metabolic domain determines what researchers or clinicians should follow during treatment.
A useful strategy should track the metabolic domains most relevant to the drug’s expected actions and observed effects, including glucose, lipids, electrolytes, and body weight when appropriate. It should also record treatment timing and dose changes, because effects may appear during therapy or after adjustments. Structured follow-up supports earlier recognition and more informed assessment of treatment safety.
During drug development, investigators assess whether observed metabolic changes align with the drug’s pharmacological actions and whether they could affect treatment safety or adherence. Findings can help identify patients at greater risk and guide the selection of monitoring strategies. This evaluation also supports benefit-risk decisions, helping teams judge whether therapeutic benefits justify unintended metabolic consequences.
They are especially important when a treatment’s metabolic changes could reduce adherence, affect safety, or influence long-term health. Pharmacologists and clinicians can use characteristic patterns to identify patients who may be at greater risk and to balance therapeutic benefit against unintended effects. This perspective keeps metabolic monitoring connected to practical treatment decisions rather than viewing changes in isolation.