Silicone Oil Injection

Silicone oil injection is a vitreoretinal procedure in which medical-grade silicone oil is placed inside the eye to provide long-term internal support for a detached or surgically repaired retina. The oil’s buoyancy and interfacial tension help press the retina against the underlying tissue, while its relative stability allows prolonged tamponade when gas is unsuitable or insufficient. In ophthalmic pharmacology and drug-delivery research, silicone oil also provides a model for studying the behavior, retention, and compatibility of injected materials in the eye. Clinical use requires monitoring for emulsification, increased intraocular pressure, cataract formation, and corneal changes, and the oil may require later removal.

Silicone Oil Injection - Related Videos

Research

JoVE Journal - Engineering

Improved Polydimethylsiloxane (PDMS) Double Casting via Silicone Oil Treatment for Densely Packed Microstructure Replication

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2025

This protocol presents an improved demolding procedure for the Polydimethylsiloxane (PDMS) double casting technique by introducing silicone oil as a non-adhesive barrier between PDMS layers. Unlike plasma or chemical surface modification methods, this approach requires no specialized or costly equipment, making it a more accessible and cost-effective alternative.

A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice

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Cited by 33 •

2019

Here, we present a protocol to induce ocular hypertension and glaucomatous neurodegeneration in mouse eyes by intracameral injection of silicone oil and the procedure for silicone oil removal from the anterior chamber to return elevated intraocular pressure to normal.

Enhanced Oil Recovery using a Combination of Biosurfactants

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Cited by 2 •

2022

We illustrate the methods involved in screening and identification of the biosurfactant producing microbes. Methods for chromatographic characterization and chemical identification of the biosurfactants, determining the industrial applicability of the biosurfactant in enhancing residual oil recovery are also presented.

Measurement of H2S in Crude Oil and Crude Oil Headspace Using Multidimensional Gas Chromatography, Deans Switching and Sulfur-selective Detection

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Cited by 11 •

2015

A multidimensional gas chromatography method for the analysis of dissolved hydrogen sulfide in liquid crude oil samples is presented. A Deans switch is used to heart-cut light sulfur gases for separation on a secondary column and detection on a sulfur chemiluminescence detector.

Two-Dimensional X-Ray Angiography to Examine Fine Vascular Structure Using a Silicone Rubber Injection Compound

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Cited by 2 •

2019

This study presents a simple two-dimensional angiographic method to examine fine vascular structures using a silicone rubber injection compound and soft tissue X-ray system.

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