Brain Activity

Brain activity refers to the electrical and chemical signaling that occurs among neurons and supports perception, thought, emotion, learning, and behavior. It arises when neurons exchange information through synapses, producing coordinated patterns across brain regions that change with sensory input, internal states, and ongoing tasks. In psychology, researchers measure these patterns with methods such as electroencephalography (EEG), functional magnetic resonance imaging (fMRI), and behavioral experiments to relate neural processes to cognition and behavior. Studying brain activity helps clarify mechanisms of memory, attention, emotion, and mental disorders while informing assessment, intervention, and models of how the mind operates.

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JoVE EoE - Neurophysiology

In Vivo Electrophysiological Recordings of Brain Activities from Multiple Sites in Rats

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2025

This video demonstrates the detailed procedure for preparing an anesthetized rat for electrophysiological recordings of brain activity from multiple sites. The scalp is dissected to access the skull, and holes are drilled at precise locations to install and secure electrodes. Tungsten microwire electrodes are then inserted into the targeted location to record the data.

Functional Near-Infrared Spectroscopy for Recording Brain Activity During Social Interactions

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2025

Source: Reindl, V., et al. Conducting Hyperscanning Experiments with Functional Near-Infrared Spectroscopy. J. Vis. Exp. (2019) This video demonstrates the use of functional near-infrared spectroscopy (fNIRS) to measure brain activity during social interactions. Participants engage in a coordinated task that increases activity in the prefrontal cortex, a region critical for social behavior, while the system detects changes in light absorption due to blood oxygenation. By analyzing the synchrony...

Measuring Proteasome Activity in Different Subcellular Compartments of the Rat Brain

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2025

This video demonstrates how to measure proteasome activity in different subcellular compartments of the lateral amygdala from fear-conditioned and control rat brains using a fluorogenic peptide assay. The proteasome cleaves the fluorogenic peptide substrate, releasing fluorescent molecules, which are quantified using a plate reader to assess proteasome activity in the nuclear and synaptic protein fractions. Increased nuclear activity suggests changes in gene expression, while reduced synaptic...

Live Imaging of Ependymal Cell Ciliary Activity in a Mouse Brain Section

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2025

Source: Al Omran, A. J., et al. Live Imaging of the Ependymal Cilia in the Lateral Ventricles of the Mouse Brain. J. Vis. Exp. (2015). This video demonstrates a live-imaging technique using differential interference contrast (DIC) microscopy to observe the beating of ependymal cilia in sagittal mouse brain sections. Ependymal cilia propel cerebrospinal fluid (CSF), and their activity is recorded in brain sections maintained in a nutrient-rich medium and imaged in a climate-controlled chamber.

Imaging Hippocampal Neuronal Activation In Mouse Brain Sections

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2025

Source: Provenzano, G., et al. Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders. J. Vis. Exp. (2015)This video demonstrates immunohistochemical imaging to visualize hippocampal neuronal activation. Stained brain sections reveal darker regions under a bright-field microscope, indicating activated neurons.

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