Mouse Dissection
Mouse Dissection - Related Videos
09:57
Dissection of 6.5 dpc Mouse Embryos
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Cited by 28 •
2007
Isolation of postimplantation-stage embryos allows one to study gene patterning and analyze cell-lineage decision making processes during embryonic development, but proper dissection of the early embryo can be challenging. This protocol describes a method for isolating early primitive-streak-stage embryos (~6.5 days post coitum [dpc]).
08:30
Dissection and Culture of Mouse Embryonic Kidney
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Cited by 4 •
2017
This protocol describes a method for isolating and culturing metanephric rudiments from mouse embryos.
12:02
Whole Mount Dissection and Immunofluorescence of the Adult Mouse Cochlea
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Cited by 85 •
2016
We present a method to isolate the adult organ of Corti as three intact cochlear turns (apex, middle, and base). We also demonstrate a procedure for immunostaining with fluorescently tagged antibodies. Together these techniques allow the study of hair cells, supporting cells, and other cell types found in the cochlea.
08:21
Dissection of the Mouse Pancreas for Histological Analysis and Metabolic Profiling
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Cited by 14 •
2017
This video article provides a detailed demonstration of the procedures required to successfully remove the pancreas from a mouse by dissection for histological analysis and metabolic profiling.
16:47
Dissection of a Mouse Eye for a Whole Mount of the Retinal Pigment Epithelium
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Cited by 45 •
2011
A formal demonstration of the dissection of a mouse eye, resulting in a whole mount of the retinal pigment epithelium.
FAQs
Preserving tissue orientation and morphology is essential because anatomical relationships can be assessed before structures are removed or processed. During Mouse dissection, careful isolation helps maintain the appearance and position of tumors relative to nearby organs. This supports visual assessment and produces samples better suited to histology and molecular analyses.
Examining organs beyond the primary tumor broadens the assessment of disease. The liver, lungs, spleen, and lymph nodes may show pathological changes, metastatic involvement, or treatment-related effects. Comparing these tissues with the tumor can indicate whether cancer has spread and whether an intervention affects multiple anatomical sites.
Tumor location and size provide anatomical observations that can be compared with tissue findings and disease progression. When researchers examine these features alongside changes in organs and lymph nodes, they gain a broader view of how a cancer model develops. These measurements also help identify specimens for more detailed histological or molecular analysis.
Visual examination provides an initial account of tumor appearance, organ changes, and anatomical relationships before specimens are processed. Researchers can then associate each collected tissue with its observed location and condition. Histology examines tissue structure, whereas molecular analyses provide additional information, allowing gross findings to be investigated through complementary approaches.
Tumors should be considered together with organs and tissues that may reveal related pathological changes, including the liver, lungs, spleen, and lymph nodes. Collecting these sites alongside the tumor supports assessment of possible metastasis and treatment-related effects. The resulting specimens can undergo histology or molecular analyses to characterize disease-associated changes.
Mouse dissection connects visible anatomical findings with tissue-based evidence of treatment response. Researchers can compare tumor features and changes in organs across disease or treatment conditions, then examine collected samples histologically or molecularly. This combination helps evaluate therapeutic responses, identify treatment-related changes, and improve interpretation of cancer-model outcomes.