Orthotopic Tumor Resection
Orthotopic Tumor Resection - Related Videos
03:58
Brain Tumor Resection in a Mouse Using a Minimally Invasive Resection System
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2025
Source: Alomari, S., et al. Implementation of Minimally Invasive Brain Tumor Resection in Rodents for High Viability Tissue Collection. J. Vis. Exp. (2022)This video demonstrates the use of a minimally invasive resection system (MIRS) to excise tumor tissue from an anesthetized mouse implanted with a tumor. The procedure involves securing the mouse onto a stereotactic frame, reopening the previous surgical site to access the brain, and inserting a specialized cannula that utilizes suction and a...
07:55
The Influence of Liver Resection on Intrahepatic Tumor Growth
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Cited by 6 •
2016
A high incidence of tumor recurrence after resection of liver metastases remains an unsolved problem. The illustrated mouse model may be useful to investigate the reasons for such recurrences. It combines a liver resection model with intrahepatic tumor cell injection for the first time.
06:23
A Murine Orthotopic Bladder Tumor Model and Tumor Detection System
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Cited by 8 •
2017
This protocol describes the generation of murine orthotopic bladder tumors in female C57BL/6J mice and the monitoring of tumor growth.
03:59
Orthotopic Homograft Tumor Transplantation: A Technique to Generate Pancreatic Tumor Mouse Models
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2023
The video explains a stepwise surgical method for orthotopic implantation of a tumor fragment from a cancerous donor to the pancreas of a non-cancerous recipient mice for development of pancreatic cancer. Orthotopically implanted PDAC could recapture the tissue microenvironment of human pancreatic cancers than conventional subcutaneous (SC) models more accurately.
07:59
Translationally-Relevant Tumor Resection Model for Murine Preclinical Models of Oral Squamous Cell Carcinoma
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2026
A unique method to surgically resect oral squamous cell carcinoma tumors established in the oral cavity is shown here.
FAQs
The organ-specific setting preserves local tumor-host interactions that influence cancer growth and treatment response. These interactions include invasion into surrounding tissue and the development of tumor-associated vasculature. Because the tumor remains within its relevant anatomical context, investigators can examine how surgery and subsequent therapies affect disease behavior under conditions that better represent localized cancer progression.
Defined margins create a controlled way to investigate whether tumor cells remain after excision. The presence or absence of residual disease can then be related to postoperative progression and recurrence. Standardizing the margin also helps investigators compare surgical strategies and evaluate whether an adjuvant treatment changes outcomes after tumor removal.
This approach can reveal how local invasion, vascularization, postoperative progression, and metastasis change after surgery. Tumor size alone does not capture these processes or the influence of the surrounding tissue. Tracking them helps researchers assess whether a treatment affects the broader course of disease rather than only the original mass.
Investigators can examine treatment response in the period after tumor excision, when residual disease may influence recurrence or further progression. The model supports testing adjuvant treatments in relation to surgical removal and allows outcomes to be interpreted alongside metastasis and local tumor-host interactions. This connects therapeutic effects to a clinically relevant postoperative setting.
A typical study implants tumor cells or tissue into the corresponding organ or tissue, allows a localized mass to establish, and then removes it under controlled conditions. Investigators may leave defined margins to model residual disease and later analyze postoperative progression, recurrence, metastasis, or treatment response. The sequence links tumor establishment directly to surgical outcomes.
Researchers would choose it when they need to evaluate surgical strategies or therapies within the tissue context where the cancer naturally develops. The model is especially relevant for studying localized disease, residual tumor after excision, postoperative recurrence, metastasis, and adjuvant treatment. Its value comes from connecting surgical intervention with biologically representative tumor-host behavior.