Tumor Localization
Tumor Localization - Related Videos
04:13
A Technique to Assess the In Vivo Localization of Tumor-Specific Antibodies
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2025
This video demonstrates a technique to study the in vivo localization of tumor-specific antibodies in a mouse tumor xenograft model. Upon subcutaneously injecting cancer cells into mice for tumor formation, fluorescently-labeled antibodies are injected that bind to tumor-specific receptors, enabling in vivo assessment of antibody localization via imaging.
10:31
Intraoperative Gastroscopy for Tumor Localization in Laparoscopic Surgery for Gastric Adenocarcinoma
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Cited by 12 •
2016
In early gastric cancer, the aim of surgery is to precisely remove the distal stomach including the primary tumor. To do this, accurate localization of the tumor is crucial, especially in totally laparoscopic surgery. This protocol describes a procedure for intraoperative gastroscopy in totally laparoscopic subtotal gastrectomy.
03:10
In Vivo Fluorescence Imaging to Localize Antibodies in a Mouse Tumor Xenograft Model
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2025
The video demonstrates a fluorescence imaging method for in vivo antibody localization in a mouse tumor xenograft model. It involves the injection of tumor cells in a mouse to generate solid xenografts beneath the skin. Subsequent injection of fluorescent antibodies confirms specific localization through enhanced fluorescence signals within the tumor xenograft.
02:43
Tumor Implantation and Injection of a Tumor Vaccine in a Mouse Model
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2025
This video demonstrates a cell-based tumor vaccination assay. A mouse, intradermally injected with B16-F10 melanoma cells for tumor formation, is vaccinated with B16-F10 cells secreting Flt3L cytokine near the developed tumor. The secreted Flt3L from the vaccine promotes the maturation and proliferation of dendritic cells that then present tumor antigens to T cells in lymph nodes, triggering a targeted anti-tumor immune response.
12:42
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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Cited by 17 •
2019
This protocol describes a detailed workflow for the generation and ex vivo characterization of oncolytic viruses for expression of immunomodulators, using measles viruses encoding bispecific T cell engagers as an example. Application and adaptation to other vector platforms and transgenes will accelerate the development of novel immunovirotherapeutics for clinical translation.
FAQs
Contrast agents emphasize differences in tissue structure or blood flow, while targeted tracers highlight cellular activity through molecular imaging. These signals increase the visibility of biologically or anatomically distinct regions, allowing investigators to relate an abnormal finding to nearby tissues and characterize its extent more precisely. That added contrast supports more informed diagnostic and treatment decisions.
Anatomical information shows where a lesion lies and how far it extends, whereas functional information indicates differences in blood flow or cellular activity. Considering both adds context beyond location alone when interpreting a suspicious region. In cancer research, this combined view helps characterize disease and improves assessment of treatment-related changes.
Mapping position and extent helps researchers compare a suspected primary lesion with other abnormal sites. Its relationship to surrounding tissues provides anatomical context, while functional or molecular signals can add information about tissue behavior. Together, these observations support assessment of whether findings are localized to an original site or represent metastatic disease.
These modalities provide complementary rather than interchangeable information. MRI, CT, and ultrasound can contribute to mapping position, extent, and relationships between a lesion and surrounding tissues, while molecular imaging uses targeted tracers to highlight cellular activity. Combining the available information supports a more complete assessment than relying on a single feature alone.
First, imaging identifies the lesion's position and extent. Investigators then examine its relationship to surrounding tissues and integrate structural, blood-flow, or cellular-activity information when available. The resulting map can guide decisions about biopsy, surgery, radiation delivery, or monitoring, linking image interpretation to a specific clinical or research objective.
Precise spatial mapping helps identify where a biopsy should be directed, shows the operative relationship between a lesion and nearby tissues, and supports accurate radiation delivery. These uses connect imaging findings with physical interventions. The benefit is better alignment between the suspected disease site and the procedure intended to sample or treat it.
Researchers can compare a tumor's mapped position and extent over time to monitor growth or response to therapy. Imaging may also provide changing information about blood flow or cellular activity, depending on the method used. These serial observations help measure treatment outcomes and show whether disease changes or requires further assessment.
Tumor localization links patient-specific imaging findings with decisions about diagnosis, biopsy, treatment planning, and follow-up. By showing the lesion's extent, tissue relationships, and potentially its functional or molecular characteristics, it supports evaluation of interventions tailored to the observed disease pattern. This makes localization valuable in both cancer research and individualized care.