Nanoparticle Surface Modification
Nanoparticle Surface Modification - Related Videos
07:58
Bio-inspired Polydopamine Surface Modification of Nanodiamonds and Its Reduction of Silver Nanoparticles
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Cited by 5 •
2018
A facile protocol is presented to functionalize the surfaces of nanodiamonds with polydopamine.
12:31
Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
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Cited by 14 •
2012
Adenovirus particles are engineered to contain either the unnatural amino acid analogue azidohomoalanine or the azido sugar O-GlcNAz. The azide group of each is chemoselectively ligated via "click" chemistry reactions as a means of viral surface modification.
14:48
PDMS Device Fabrication and Surface Modification
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Cited by 5 •
2007
09:12
Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
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Cited by 15 •
2018
We have engineered the capsid protein of hepatitis E virus as a theranostic nanoparticle (HEVNP). HEVNP self-assembles into a stable icosahedral cage in mucosal delivery. Here, we describe the modification of HEVNPs for tumor targeting by mutating surface-exposed residues to cysteines, which conjugate synthetic ligands that specifically bind tumor cells.
10:27
The Evolution of Silica Nanoparticle-polyester Coatings on Surfaces Exposed to Sunlight
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Cited by 12 •
2016
Two types of surfaces, polyester-coated steel and polyester coated with a layer of silica nanoparticles, were studied. Both surfaces were exposed to sunlight, which was found to cause substantial changes in the chemistry and nanoscale topography of the surface.
FAQs
These attachment modes create different types of contact between a modifier and the nanoparticle surface. Adsorption places the modifier at the interface, covalent bonding forms a chemical connection, and electrostatic interactions use charge-based attraction. Encapsulation and inorganic coatings provide additional ways to surround or cover the core, allowing chemists to tune stability, charge, solubility, or reactivity.
The modifier and its attachment chemistry should match the intended environment. Molecules, polymers, and ligands can alter how the particle interacts with solvents or biomolecules, while inorganic coatings create a different outer interface. Because these choices affect dispersion, solubility, charge, and reactivity, selecting the surface component tunes performance while leaving the nanoparticle core composition unchanged.
Aggregation is controlled by changing interactions at the outer interface rather than replacing the nanoparticle core. A suitable surface layer can improve dispersion and stability, helping particles remain more uniformly distributed in a solvent or surrounding medium. This matters because aggregation can alter material behavior and interfere with intended interactions with biomolecules or other materials.
Surface modification separates core and interface functions. The core retains its composition, while the altered outer layer governs contact with solvents, biomolecules, or other materials. Chemists can therefore adjust solubility, charge, stability, or reactivity without redesigning the nanoparticle itself. This approach is useful when performance depends mainly on interfacial behavior rather than on changing the core.
A basic workflow starts by identifying the interfacial property that needs control, such as stability, solubility, charge, or reactivity. The researcher then selects a molecule, polymer, ligand, or inorganic coating and an attachment route, including adsorption, covalent bonding, electrostatic interaction, or encapsulation. The resulting interface is assessed by its effects on dispersion and surrounding interactions.
Tailored nanoparticle interfaces support catalysis, sensors, drug delivery, imaging, and environmental remediation. In each application, the surface layer regulates how the particle interacts with its surroundings, including solvents, biomolecules, or other materials. Chemistry researchers can consequently adjust properties such as stability, solubility, charge, and reactivity to better match the needs of a particular use.