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Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
Chapters
Summary August 19th, 2012
Adenovirus particles are engineered to contain either the unnatural amino acid analogue azidohomoalanine or the azido sugar O-GlcNAz. The azide group of each is chemoselectively ligated via "click" chemistry reactions as a means of viral surface modification.
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