Acne Vulgaris
Acne Vulgaris - Related Videos
01:27
Acne Infection
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2026
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
03:10
A Rat Model of Compound Acne
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Cited by 1 •
2024
This protocol outlines the procedure for inducing acne inflammation in rat skin with oleic acid and Cutibacterium acnes.
08:00
Agrobacterium tumefaciens-Mediated Genetic Engineering of Green Microalgae, Chlorella vulgaris
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Cited by 3 •
2023
This protocol outlines the utilization of Agrobacterium tumefaciens-mediated transformation (AMT) for integrating gene(s) of interest into the nuclear genome of the green microalgae Chlorella vulgaris, leading to the production of stable transformants.
10:26
The Infiltration-centrifugation Technique for Extraction of Apoplastic Fluid from Plant Leaves Using Phaseolus vulgaris as an Example
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Cited by 100 •
2014
This protocol details the optimized extraction of apoplast washing fluid from plant leaves, using French bean plants (Phaseolus vulgaris) as a model example.
14:02
Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry
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Cited by 30 •
2017
This paper describes a methodology to prepare cardiovascular tissue samples for MS analysis that allows for (1) the analysis of ECM protein composition, (2) the identification of glycosylation sites, and (3) the compositional characterization of glycan forms. This methodology can be applied, with minor modifications, to the study of the ECM in other tissues.
FAQs
Follicular hyperkeratinization contributes to pore blockage by increasing the buildup of keratin within the follicle. When this process occurs alongside increased sebum production, the pilosebaceous unit becomes obstructed, creating conditions in which lesions can develop. Addressing this paired process is therefore central to treatment strategies aimed at reducing acne lesions.
Cutibacterium acnes can proliferate after follicular blockage and activate local inflammation. This inflammatory response helps explain why acne may progress beyond a blocked pore to papules, pustules, or more severe lesions. The organism is therefore relevant not only to the presence of acne, but also to the inflammatory character and clinical range of the disease.
Hormonal signaling can intensify acne by reinforcing the underlying follicular and sebaceous changes. In practice, this means that lesion development is not determined by blockage or microbial proliferation alone. Recognizing hormonal influence helps explain why treatment plans may include hormonal therapies for appropriate patients, alongside options directed at other parts of the disease process.
Treatment selection is guided primarily by disease severity and the risk of scarring. Topical retinoids, benzoyl peroxide, antibiotics, hormonal therapies, and isotretinoin are available options, but the overview does not imply that every patient needs all of them. Matching therapy to clinical severity supports lesion control while addressing the possibility of permanent skin damage.
Topical retinoids and benzoyl peroxide are topical treatment options for acne vulgaris. Their inclusion alongside antibiotics, hormonal therapies, and isotretinoin reflects the need for different therapeutic approaches rather than a single universal regimen. In medical management, these options are considered within the broader goal of reducing active lesions and limiting the risk of scarring.
Effective management has goals beyond clearing visible lesions: it can reduce ongoing acne activity, help prevent permanent skin damage, and improve psychosocial well-being. These outcomes explain why treatment planning considers both current severity and scarring risk. Acne care therefore addresses active disease and its potential longer-term physical and emotional consequences.