Inflammation Assessment
Inflammation Assessment - Related Videos
02:49
A Technique to Assess the Immune Response against an Antigen by Inducing Skin Inflammation
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2025
This video demonstrates an in vivo technique to assess a test antigen by inducing skin inflammation in a murine model. The test antigen—a hapten in an oil/acetone solution—is topically applied to the skin of the mouse ear, and inflammation of the skin is assessed after an adequate period.
04:06
Using Fluorescence-Mediated Tomography to Assess Murine Intestinal Inflammation
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2025
This video demonstrates a technique for assessing intestinal macrophage infiltration in a murine model of colitis using fluorescence-mediated tomography (FMT). Upon inducing colitis in a mouse via dextran sodium sulfate (DSS), the animal is injected with antibodies that recognize the F4/80 glycoprotein marker on infiltrated macrophages in the colon. The mouse is then imaged in an FMT device where the fluorescence and reflectance signals are reconstructed into a three-dimensional image to...
01:38
Inflammation
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2019
Overview In response to tissue injury and infection, mast cells initiate inflammation. Mast cells release chemicals that increase the permeability of adjacent blood capillaries and attract additional immune cells to the wound or site of infection. Neutrophils are phagocytic leukocytes that exit the bloodstream and engulf invading microbes. Blood clotting platelets seal the wound and fibers create a scaffold for wound healing. Macrophages engulf aging neutrophils to end the acute inflammatory...
07:38
Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing
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Cited by 18 •
2016
Accurate assessment of anti-inflammatory effects is of utmost importance for the evaluation of potential new drugs for the treatment of inflammatory bowel disease. Digital holographic microscopy provides assessment of inflammation in murine and human colonic tissue samples as well as automated multimodal evaluation of epithelial wound healing in vitro.
08:43
Investigating Intestinal Inflammation in DSS-induced Model of IBD
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Cited by 607 •
2012
Experimental models of inflammatory bowel disease have allowed us to examine the complex innate and adaptive immune responses associated with pathogenesis. Using histological scoring, quantification of pro-inflammatory cytokines and myeloperoxidase activity, one can begin to assess these responses seen in inflammatory bowel disease.
FAQs
Immune-cell activation releases inflammatory mediators that contribute to tissue responses and clinical findings such as pain, swelling, warmth, and fever. These effects provide observable evidence of inflammation, while laboratory measures offer additional information about immune activity. Considering both types of evidence helps clinicians characterize the inflammatory process more reliably than relying on a single finding.
Each measure provides a different laboratory view of inflammatory activity, so their combined interpretation can strengthen clinical assessment. C-reactive protein, erythrocyte sedimentation rate, and leukocyte counts should be considered alongside symptoms, physical findings, and relevant disease-specific biomarkers. This integrated approach reduces the risk of treating one laboratory result as a complete explanation of the patient's condition.
The distinction depends on the pattern of findings over time and their relationship to the clinical context. A short-term protective response may accompany temporary tissue injury or another acute problem, whereas persistent findings may support ongoing inflammatory disease. Repeated clinical and laboratory assessment can help determine whether inflammation is resolving, continuing, or changing during care.
Disease-specific biomarkers add targeted information when general measures do not fully explain the clinical picture. Used with symptoms, examination findings, and broader tests such as leukocyte counts or inflammatory markers, they can help characterize inflammation associated with a particular disorder. Their value lies in improving context-specific interpretation rather than replacing the overall assessment.
Assessment begins with symptoms and physical findings, including pain, swelling, warmth, and fever. Clinicians then select laboratory measures such as C-reactive protein, erythrocyte sedimentation rate, leukocyte counts, or disease-specific biomarkers when appropriate. Finally, they interpret the combined results in clinical context to identify, characterize, or monitor inflammation and inform care.
Clinicians can use serial assessment when they need to evaluate response to therapy or follow the course of an inflammatory condition. Comparing symptoms, physical findings, and laboratory measures over time may show whether inflammatory activity is improving or persisting. The results can therefore support treatment decisions while keeping interpretation linked to the patient's broader clinical status.
Inflammation assessment supports evaluation across several clinical settings, including infections, autoimmune disorders, tissue injury, and chronic inflammatory disease. The specific combination of examination findings, general laboratory measures, and disease-specific biomarkers depends on the clinical question. In each setting, the assessment helps identify inflammatory activity and monitor how the condition changes during care.