Migratory Polarity
Migratory Polarity - Related Videos
10:10
In Vivo Imaging Uncovers the Migratory Behavior of Leukocytes within the Joints
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2025
In vivo imaging of the joints is a valuable technique for uncovering the migratory behavior of leukocytes and molecular dynamics within the inflamed joints. Here, we present a detailed protocol for in vivo imaging of the joints using a murine model of type II collagen-induced arthritis (CIA).
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Group Polarization
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2020
Group polarization is the strengthening of an original group attitude following the discussion of views within a group (Teger & Pruitt, 1967). That is, if a group initially favors a viewpoint, after discussion the group consensus is likely a stronger endorsement of the viewpoint. Conversely, if the group was initially opposed to a viewpoint, group discussion would likely lead to stronger opposition. The phenomenon of group polarization explains many actions taken by groups that would not...
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Wound Assay to Evaluate the Migratory Capacity of Murine Myoblasts in Co-Culture
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2025
This video describes a non-contact co-culture wound healing assay to evaluate the migratory capacity of murine myoblasts. This helps to understand signal-sending and signal-receiving components of the paracrine non-canonical Wnt signaling interactions in vitro.
06:34
Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures
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Cited by 1 •
2011
Time lapse imaging of 3D tissue culture allows studying migratory behavior of individual cells originating from ganglionic eminence in reaction to fractionated protein extract from cerebral cortex.
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Molecular Shape and Polarity
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2020
Dipole Moment of a Molecule Polar covalent bonds connect two atoms with differing electronegativities, leaving one atom with a partial positive charge (δ+) and the other atom with a partial negative charge (δ–), as the electrons are pulled toward the more electronegative atom. This separation of charge gives rise to a bond dipole moment. The magnitude of a bond dipole moment is represented by the Greek letter mu (µ) and is given by the formula shown here, where Q is the magnitude of the...
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Extracellular guidance cues regulate the remodeling of actin and microtubules, two cytoskeletal systems that help organize cellular movement. Their influence supports extension of the leading process and helps establish a consistent direction of travel. In developing neurons, this cue-responsive remodeling connects signals outside the cell with the internal organization required for migration.
Positioning the centrosome and Golgi apparatus ahead of the nucleus aligns internal cell organization with the direction of movement. This arrangement accompanies extension of the leading process and supports coordinated forward displacement. Studying these organelles therefore reveals how neuronal cells translate directional polarity into an organized migratory behavior during nervous system development.
Actin and microtubule remodeling provides a cellular basis for maintaining a front and rear during movement. These changes help coordinate the leading process with the locations of the centrosome, Golgi apparatus, and nucleus. When these structures remain spatially organized, the neuron can move efficiently toward its appropriate position as development proceeds.
A focused analysis should consider the direction of the leading process, the organization of actin and microtubules, and the relative positions of the centrosome, Golgi apparatus, and nucleus. These features provide complementary evidence about polarity and movement. Examining them together helps connect extracellular guidance cues with the positioning behavior of developing neurons.
Migratory polarity helps developing neurons reach their proper locations, making it relevant to the organization of the cerebral cortex. Directional movement links cellular behavior with the eventual arrangement of neural cells. Research on this process can therefore clarify how coordinated migration contributes to cortical structure during nervous system development.
The directional organization used during neuronal migration is relevant to later aspects of neural development, including axon and dendrite development. Investigating how guidance cues, cytoskeletal remodeling, and organelle positioning coordinate movement provides context for understanding neuronal organization more broadly. This work also helps relate disrupted cell positioning to neurodevelopmental disorders.