Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Matthias Ernst; Adele Preaudet; Tracy Putoczki

doi:10.3791/52383

/

Tıp

/

Canlı Fareler Seri endoskopik Görüntüleme kullanma Bağırsak Patolojilerde Yeni Therapeutics Etkinliğinin Non-invaziv Değerlendirme

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

JoVE Journal
Tıp

This content is Free Access.

JoVE Journal Tıp

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Canlı Fareler Seri endoskopik Görüntüleme kullanma Bağırsak Patolojilerde Yeni Therapeutics Etkinliğinin Non-invaziv Değerlendirme

Please note that all translations are automatically generated. Click here for the English version.

9,946 Views

•

09:01 min

•

March 10, 2015

DOI:

10.3791/52383-v

DOI:

10.3791/52383-v

•

09:01 min

March 10, 2015

•

6 Views

Matthias Ernst^1,2,3, Adele Preaudet¹, Tracy Putoczki^1,2

¹The Walter and Eliza Hall Institute for Medical Research, ²The Department of Medical Biology,University of Melbourne, ³Olivia Newton-John Cancer Research Institute

Özet

We describe methods for longitudinal monitoring of the efficacy of therapeutics for the treatment of colonic pathologies in mice using a rigid endoscope. This protocol can be readily used for the characterization of the therapeutic response of an individual tumor in live mice and also for monitoring potential disease relapse.