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Immune Response Against Viral Pathogens

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Upon viral infection, cells secrete interferons to protect uninfected cells and activate the patrolling NK cells to initiate a non-specific innate immune response.

These NK cells have pathogen recognition receptors that recognize diverse viral antigens on infected cells and eliminate them by cell lysis.

The lysed virus-infected cells release viral antigens that are engulfed by APCs like dendritic cells, which display them with both MHC I and MHC II.

The antigen-MHC I complex is presented to antigen-specific naive CD8 T cells, which differentiate into cytotoxic T cells to kill virus-infected cells.

In contrast, the antigen-MHC II complex activates antigen-specific CD4 T cells, giving rise to helper T cells.

These cells enhance cytotoxic T cell activity for the destruction of infected cells.

Additionally, helper T cells activate B cells, whose receptors can directly bind free viral particles, differentiating into antibody-producing plasma cells.

These secreted antibodies bind other free viral particles, preventing them from penetrating target cells and marking them for neutralization by phagocytes.

Overview

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The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.

NK Cells

NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory cytokines that aid in controlling the disease.

T Cells

T cells are pivotal in responding to viral infections. CD8 cytotoxic T lymphocytes recognize and kill virus-infected cells, helping clear the infection. Concurrently, CD4 T cells act as helper cells, supporting the immune response by aiding in the production of antibodies and enhancing the activity of CD8 T cells.

Antibodies

Antibodies, produced by B cells, provide another layer of defense against viral infections. They bind to free viral particles, preventing these viruses from attaching to or penetrating target cells. This action neutralizes the virus, preventing further spread of the infection.

While a robust immune response is crucial for clearing viral infections, an overactive response can lead to autoimmunity, where the immune system inadvertently causes tissue damage. CD8 T cells and CD4 T cells, particularly Th1 cells, can contribute to this immunopathology.

Regulatory T Cells (Tregs)

Regulatory T cells are critical in controlling the immune response and limiting excessive immunopathology. By suppressing overactive immune responses, Tregs help maintain a balance, ensuring that the immune system effectively combats the virus without causing undue damage to the body's tissues.

Understanding the intricate immune responses to viral infections is vital for developing effective vaccines and therapies.

Transcript

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Immune Response

Viral Pathogens

Natural Killer Cells

T Cell Response

Antibody Mediated Immunity

Cytotoxic T Lymphocytes

Regulatory T Cells

Immunopathology Control

Vaccine Development