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Focal Cerebral Ischemia Model by Endovascular Suture Occlusion of the Middle Cerebral Artery in the Rat
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Chapters
- 00:05Title
- 01:51Presurgical Preparations
- 03:01MCAO Surgery
- 10:41Reperfusion (Suture Removal)
- 11:52Post-MCAO Behavior
- 12:52Identifying Brain Infarct by 2,3,5-Triphenyltetrazolium Chloride (TTC)
Surgical induction of ischemic brain damage in the rat is a widely used model for stroke research. Here we demonstrate the induction of focal cerebral ischemia by occlusion of the middle cerebral artery. Visualization of the resulting infarct by histological staining and magnetic resonance imaging is also shown.
Tags
Focal Cerebral Ischemia ModelEndovascular Suture OcclusionMiddle Cerebral ArteryRat StrokeReproducibilityExperimentally Induced Infarct VolumeAnimal ModelAnimal Husbandry CostsCranial CirculationMiddle Cerebral Artery OcclusionRecanalizationReperfusionEndovascular Suture MCAO ModelSpontaneously Hypertensive Rat (SHR)Filament With Silicon Tip CoatingOptimal Occlusion PeriodBehavioral Indicators Of StrokeT2-weighted Magnetic Resonance ImagesBrain Sections Staining
