JoVE Encyclopedia of Experiments
Neuroscience
0 views • 6:02 min • August 29th, 2025
Begin with a participant fitted with stimulation electrodes on the tibial nerve to induce peripheral nerve stimulation, and EMG electrodes on the soleus muscle to record muscle contraction.
Electrically stimulate the nerve to deliver PNS, sending sensory signals to the spinal cord and triggering muscle contraction, called the H-reflex.
Stabilize the participant's head on a table. Position the TMS coil over the primary motor cortex.
Apply magnetic stimulation to activate cortical neurons, sending signals down the corticospinal tract and inducing muscle contraction.
Next, position a CMS coil over the cervicomedullary junction.
Apply magnetic stimulation to directly activate corticospinal axons, bypassing the motor cortex.
Pair TMS with PNS and CMS with PNS separately to examine the influence of each stimulation site on the H-reflex.
Apply low-frequency repetitive-TMS to reduce corticospinal excitability.
Repeat TMS with PNS and CMS with PNS to evaluate whether rTMS altered cortical or spinal transmission and affected the H-reflex.
First, perform the calibration procedure for the neuro-navigational system. Use a figure eight coil to stimulate the subject's motor cortical area, contralateral to
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