Question 1

How do you perform subcutaneous injection in rabbits?

Accepted Answer

Lift the loose skin over the shoulder region to create a skin tent. Insert a 20–25 G needle beneath the skin, inject the compound slowly, and withdraw the needle. Injection volumes should not exceed 5 mL/kg. Proper restraint minimizes stress and ensures accurate delivery of the compound.

Question 2

What is the correct technique for intramuscular injection in rabbits?

Accepted Answer

Firmly secure the rabbit's hindquarters to prevent kicking. Insert a 20–25 G needle into the lateral thigh muscle and briefly aspirate to check for blood. If no blood appears, slowly inject the compound and withdraw the needle. Injection volumes should not exceed 0.25–0.5 mL per kg.

Question 3

How is intravenous administration performed in rabbits?

Accepted Answer

Restrain or sedate the rabbit, shave the ear, and disinfect the site with antiseptic solution. Insert a catheter into the marginal ear vein and secure it before administering the compound. Alternatively, use a 21–22 G needle for direct injection. Apply gentle pressure afterward to prevent hematoma formation.

Question 4

What preparation steps are needed before administering compounds to rabbits?

Accepted Answer

Calculate the appropriate dose based on the rabbit's body weight and prepare all materials using aseptic technique. Ensure proper restraint and handling to minimize stress and prevent injury. All procedures must follow institutional guidelines and approved study protocols to ensure accurate compound delivery.

Question 5

What should you monitor after compound administration in rabbits?

Accepted Answer

Monitor the rabbit for pain, distress, hemorrhage, swelling, hematoma formation, and tissue necrosis at the administration site. Observe behavior, mobility, and overall clinical condition to ensure animal welfare. Report any adverse reactions immediately to ensure the rabbit's health and successful compound delivery.

Question 6

Why is restraint important during compound administration in rabbits?

Accepted Answer

Proper restraint prevents kicking, injury, and stress during injection procedures. It ensures accurate needle placement and compound delivery to the correct anatomical site. Restraint also protects both the animal and the handler, maintaining safety and procedure integrity throughout the administration process.

Question 7

What are the key differences between subcutaneous and intramuscular injection sites in rabbits?

Accepted Answer

Subcutaneous injections target the loose skin over the shoulder region with volumes up to 5 mL/kg. Intramuscular injections target the lateral thigh muscle with volumes not exceeding 0.25–0.5 mL per kg. Site selection depends on study objectives, required absorption profile, and characteristics of the test article.

Compound Administration in Rabbits II

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