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JoVE Journal
Bioengineering

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Measurement of Aggregate Cohesion by Tissue Surface Tensiometry
 

Measurement of Aggregate Cohesion by Tissue Surface Tensiometry

Article doi: 10.3791/2739
April 8th, 2011

Summary April 8th, 2011

We describe a method of measuring binding energy, expressible as tissue surface tension, between cells within 3D tissue-like aggregates. Differences in tissue surface tension have been demonstrated to correlate with invasiveness of lung, muscle, and brain tumors, and are fundamental determinants of establishing spatial relationships between different cell types.

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