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Journal / Biology / Efficient Derivation of Human Cardiac Precursors…
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JoVE Journal Biology
Efficient Derivation of Human Cardiac Precursors and Cardiomyocytes from Pluripotent Human Embryonic Stem Cells with Small Molecule Induction
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Efficient Derivation of Human Cardiac Precursors and Cardiomyocytes from Pluripotent Human Embryonic Stem Cells with Small Molecule Induction

Article DOI: 10.3791/3274 • 10:47 min • November 3rd, 2011
November 3rd, 2011 •
1,2, 3,4, 1,2, 1,2,5, 1,2,6, 1,2
1San Diego Regenerative Medicine Institute, 2Xcelthera, 3Department of Neurosurgery, Harvard Medical School, 4Division of SCI Research, VA Boston Healthcare System, 5Program in Stem Cell & Regenerative Biology, Sanford-Burnham Medical Research Institute, 6La Jolla IVF

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Summary
Automatic Translation

We have established a protocol for induction of cardioblasts direct from pluripotent human embryonic stem cells maintained under defined conditions with small molecules, which enables derivation of a large supply of human cardiac progenitors and functional cardiomyocytes for cardiovascular repair.

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Human Cardiac Precursors Cardiomyocytes Pluripotent Human Embryonic Stem Cells Small Molecule Induction Regenerating Human Myocardium Cell-based Transplantation Cardiac Tissue Engineering Stem/progenitor Cells Bone Marrow Cord Blood Contractile Heart Muscle Cells Adult Stem Cell Therapy Genetically Stable Human Embryonic Stem Cells Unlimited Expansion Ability Unrestricted Plasticity Large Supplies Of Human Somatic Cells Cardiovascular Disease Donor Organs HESC-based Therapies
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