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JoVE Journal
Medicine

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Modeling and Imaging 3-Dimensional Collective Cell Invasion
 

Modeling and Imaging 3-Dimensional Collective Cell Invasion

Article DOI: 10.3791/3525
December 7th, 2011

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Summary December 7th, 2011

Models of tumor cell invasion into three-dimensional extracellular matrix better reflect the in vivo situation than two-dimensional motility assays. Using matrix invasion assays combined with confocal imaging of fluorescently-labeled cells, detailed information on invasion modes and the distinct contributions of leading versus following cells can be obtained.

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